236600
C-Reactive Protein, Human Ascites
C - reactive protein, Human Ascites, CAS 9007-41-4, is a major acute-phase plasma protein that composed of five identical non-covalently linked subunits.
Synonym(s):
C-Reactive Protein, Human Ascites, CRP
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Quality Level
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
water: soluble
shipped in
wet ice
storage temp.
2-8°C
General description
M.W. 23,000 (monomer); 115,000 (pentamer).
Native C-reactive protein from human ascites. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer.
Native C-reactive protein from human ascites. Major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in the diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. 21 kDa) aggregates as a cyclic pentamer.
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Standard Handling (A)
Physical form
In 150 mM NaCl, 20 mM Tris, 2 mM CaCl₂, 0.1% NaN₃, pH 7.5.
Preparation Note
Prepared from ascites that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Analysis Note
Single band by SDS-PAGE
Other Notes
Christner, R.B., and Mortensen, R.F. 1994. J. Biol. Chem. 269, 9760.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Katrine Pilely et al.
Frontiers in immunology, 8, 1040-1040 (2017-09-14)
Inflammation is a part of the initial process leading to atherosclerosis and cholesterol crystals (CC), found in atherosclerotic plaques, which are known to induce complement activation. The pentraxins C-reactive protein (CRP), long pentraxin 3 (PTX3), and serum amyloid P component
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