Key Documents

View All Documentation

Naltrindole hydrochloride

Name: Naltrindole hydrochloride
Brand: SIGMA

≥97.5% (HPLC), solid, δ-opioid receptor antagonist

Synonym(s):

NTI hydrochloride

Select a Size

Change View

Pack Size	SKU	Availability	Price

About This Item

Empirical Formula (Hill Notation):

C₂₆H₂₆N₂O₃ · HCl

CAS Number:

111469-81-9

Molecular Weight:

450.96

UNSPSC Code:

12352200

PubChem Substance ID:

24278062

NACRES:

NA.77

MDL number:

MFCD00069313

Form:

solid

Quality level:

100

Storage condition:

desiccated

Pricing and availability is not currently available.

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Naltrindole hydrochloride, solid

form

solid

Quality Level

100

storage condition

desiccated

color

off-white

solubility

methanol: 4.5 mg/mL, H₂O: 8 mg/mL

storage temp.

−20°C

SMILES string

Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7ccccc7c6C[C@@]35O)CC8CC8

InChI

1S/C26H26N2O3.ClH/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14;/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2;1H/t20-,24+,25+,26-;/m1./s1

InChI key

KNJKRQXCFJCQHC-IDRHMUJXSA-N

Gene Information

human ... OPRD1(4985)

Description

Biochem/physiol Actions

Highly selective, non-peptide δ-opioid receptor antagonist that crosses the blood-brain barrier.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	P102	B4563	A7479
Sigma-Aldrich N115 Naltrindole hydrochloride	Sigma-Aldrich P102 R(+)-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride	Sigma-Aldrich B4563 Bisantrene dihydrochloride	Sigma-Aldrich A7479 5-AIQ hydrochloride
form solid	form solid	form solid	form solid
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level -
storage temp. −20°C	storage temp. -	storage temp. room temp	storage temp. −20°C
storage condition desiccated	storage condition -	storage condition desiccated	storage condition -
solubility methanol: 4.5 mg/mL, H₂O: 8 mg/mL	solubility H₂O: 150 mg/mL, ethanol: slightly soluble	solubility deionized water: 8 mg/mL	solubility DMSO: >20 mg/mL, H₂O: >20 mg/mL
color off-white	color white	color -	color tan

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Characterization of delta-opioid receptors and effect of enkephalins on IRD 98 rat epithelial intestinal cell line.

J L Nano et al.

Pflugers Archiv : European journal of physiology, 439(5), 547-554 (2000-04-14)

Using 3H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (3H-DADLE) as a radioligand, delta-opioid binding sites on the IRD 98 rat epithelial cell line were identified. These sites were found to be reversible, saturable, specific and displayed high affinity for DADLE. Scatchard analysis revealed a dissociation constant

Acute delta-opioid receptor activation induces CREB phosphorylation in NG108-15 cells.

W Bilecki et al.

European journal of pharmacology, 390(1-2), 1-6 (2000-03-10)

A growing body of evidence supports an important role of the transcription factor cAMP responsive element binding protein (CREB) in mediating opioid-induced changes in the cAMP pathway. Regulation of CREB and subsequent changes in gene expression may underlie some long-term

Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist.

P S Portoghese et al.

European journal of pharmacology, 146(1), 185-186 (1988-01-27)

Global Trade Item Number

SKU	GTIN
N115-5MG	04061832557366
N115-50MG	04061832557359
N115-10MG	04061832557342

Questions

Reviews

No rating value