The best practice for item H0915, Hydroxychloroquine sulfate, involves preparing the stock solution fresh before use. Although information about the stability of small molecules in solution is rare, it is generally recommended to store in PBS at -20°C. To prevent repeated freeze-thaw cycles, it is advisable to aliquot into working volumes. Additionally, the effect of storing the stock solution on compound performance should be evaluated for each specific application. When used as a cell culture supplement, the stock solution should be diluted into the culture medium immediately before use.
H0915
Hydroxychloroquine sulfate
≥98% (HPLC), powder, anti-inflammatory
Synonym(s):
Hydroxychloroquine sulfate, 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate
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All Photos(4)
About This Item
Empirical Formula (Hill Notation):
C18H26ClN3O · H2SO4
CAS Number:
Molecular Weight:
433.95
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Product Name
Hydroxychloroquine sulfate, ≥98% (HPLC), powder
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to off-white
solubility
H2O: >20 mg/mL
SMILES string
OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI
1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChI key
JCBIVZZPXRZKTI-UHFFFAOYSA-N
Gene Information
human ... TLR7(51284) , TLR9(54106)
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Application
Hydroxychloroquine sulfate has been used:
- as an inhibitor of autophagy to treat cells for apoptosis assay[1] to study the role of pirarubicin induced autophagy in bladder cancer cell line[2]
- to evaluate the antiviral mechanism of hydroxychloroquine against DENV-2 (dengue virus-2) infection by immunofluorescence assay[3]
- to inhibit lysosome fusion with the autophagosome[4]
Biochem/physiol Actions
Hydroxychloroquine is also used for treating rheumatoid arthritis and systemic lupus erythematosus.[5]
Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor.
Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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How should stock solutions of H0915, Hydroxychloroquine sulfate, be stored after reconstituting in water or PBS?
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