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86720

Sigma-Aldrich

Tetraethylthiuram disulfide

≥97.0% (S)

Synonym(s):

Bis(diethylthiocarbamoyl) disulfide, Bis(diethylthiocarbamyl) disulfide, Disulfiram, TETD

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About This Item

Linear Formula:
(C2H5)2NCSS2CSN(C2H5)2
CAS Number:
97-77-8
Molecular Weight:
296.54
Beilstein:
1712560
EC Number:
202-607-8
MDL number:
MFCD00009048
UNSPSC Code:
12352100
PubChem Substance ID:
57653188
NACRES:
NA.22

Assay

≥97.0% (S)

form

powder

mp

69-71 °C (lit.)

SMILES string

CCN(CC)C(=S)SSC(=S)N(CC)CC

InChI

1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3

InChI key

AUZONCFQVSMFAP-UHFFFAOYSA-N

Gene Information

human ... ALDH2(217) , CYP1A2(1544)

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Application

Alcohol dehydrogenase inhibitor.

Signal Word

Warning

Hazard Statements

H302,H317,H373,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT RE 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Beatriz Mothe et al.
The Journal of antimicrobial chemotherapy, 70(6), 1833-1842 (2015-03-01)
The safety, immunogenicity, impact on the latent reservoir and rebound of viral load after therapeutic HIV-1 vaccination with recombinant modified vaccinia Ankara-based (MVA-B) HIV-1 vaccine expressing monomeric gp120 and the fused Gag-Pol-Nef polyprotein of clade B with or without a
Peter M Meggyesy et al.
Molecules (Basel, Switzerland), 25(21) (2020-10-31)
The therapeutic utility of the copper ionophore disulfiram was investigated in a diet-induced obesity mouse model (C57BL/6J background), both through administration in feed (0.05 to 1% (w/w)) and via oral gavage (150 mg/kg) for up to eight weeks. Mice were
P Liu et al.
British journal of cancer, 107(9), 1488-1497 (2012-10-04)
Glioblastoma multiforme (GBM) cells are resistant to anticancer drugs. Cancer stem cells (CSCs) are a key mediator of chemoresistance. We have reported that disulfiram (DS), an aldehyde dehydrogenase (ALDH) inhibitor, targets breast CSC-like cells. In this study, the effect of
Henning Krampe et al.
Current pharmaceutical design, 16(19), 2076-2090 (2010-05-21)
Supervised intake of the alcohol deterrent (AD) disulfiram has proven to be an effective adjunct to biopsychosocial alcoholism therapy for more than 60 years. This article summarizes disulfiram literature between 1937 and 2000 and reviews 13 clinical trials of disulfiram
Kirsi Ketola et al.
PloS one, 7(12), e51470-e51470 (2012-12-20)
Current treatment options for castration- and treatment-resistant prostate cancer are limited and novel approaches are desperately needed. Our recent results from a systematic chemical biology sensitivity screen covering most known drugs and drug-like molecules indicated that aldehyde dehydrogenase inhibitor disulfiram
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