Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Understanding trans platinum complexes as potential antitumor drugs beyond targeting DNA.

Journal of inorganic biochemistry (2012-07-24)

A G Quiroga

PMID22819649

ABSTRACT

This focused review is devoted to our advances in developing trans platinum complexes as antitumoral complexes, in particular those bearing aliphatic amines. It includes some fundamental aspects of the understanding of non conventional metallodrug mechanism. The perspective is arranged by those fundamental aspects and within each section only the most successful examples have been included and also those in which clearly SAR's (structure activity relationships) have been observed.

MATERIALS

Product Number

Brand

Product Description

267821

Sigma-Aldrich

Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis

520780

Sigma-Aldrich

Platinum black, fuel cell grade, ≥99.9% trace metals basis

298093

Sigma-Aldrich

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520799

Sigma-Aldrich

Platinum black, low bulk density, ≥99.9% trace metals basis

357375

Sigma-Aldrich

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267244

Sigma-Aldrich

Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis

444685

Sigma-Aldrich

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349321

Sigma-Aldrich

Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis

349402

Sigma-Aldrich

Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis

349380

Sigma-Aldrich

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205915

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Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis

349348

Sigma-Aldrich

Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis

327484

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GF72782231

Platinum, foil, 50x50mm, thickness 0.1mm, as rolled, 99.99+%

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Platinum, foil, 10mm disks, thickness 0.0125mm, as rolled, 99.95%

771937

Sigma-Aldrich

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GF83202083

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GF96551354

Platinum, foil, 10mm disks, thickness 0.0075mm, as rolled, 99.95%

GF83172269

Platinum, foil, 0.05m coil, thickness 0.025mm, coil width .4mm, as rolled, 99.95%

GF84685236

Platinum, foil, 6mm disks, thickness 0.005mm, as rolled, 99.95%

GF98759200

Platinum, foil, not light tested, 100x100mm, thickness 0.0125mm, as rolled, 99.95%

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Platinum, wire reel, 0.1m, diameter 0.15mm, annealed, may be used as one component of a thermocouple, 99.99%

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Platinum, foil, 8mm disks, thickness 0.005mm, as rolled, 99.95%

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Platinum, wire reel, 0.1m, diameter 0.006mm, wollaston, 99.9%

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Platinum, foil, 0.1m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%

GF89210336

Platinum, foil, 4mm disks, thickness 0.025mm, as rolled, 99.95%

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Platinum, foil, 15mm disks, thickness 0.025mm, as rolled, 99.95%

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Platinum, foil, 0.2m coil, thickness 0.025mm, coil width 1.6mm, as rolled, 99.95%