902667

Propargyl-PEG6-acid

• Synonym(s): 4,7,10,13,16,19-Hexaoxadocos-21-ynoic acid, Propargyl-PEG6-CH2CO2H
• Empirical Formula (Hill Notation): C₁₆H₂₈O₈
• CAS Number: 1951438-84-8
• Molecular Weight: 348.39
• MDL number: MFCD28950778
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• Assay: ≥95%
• form: liquid
• reaction suitability: reaction type: click chemistry; reagent type: cross-linking reagent
• refractive index: n/D 1.469
• functional group: alkyne; carboxylic acid
• storage temp.: −20°C
• SMILES string: OC(CCOCCOCCOCCOCCOCCOCC#C)=O

Description

Application

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophilic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable