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Key Documents

SAB4502076

Sigma-Aldrich

Anti-Parkin antibody produced in rabbit

affinity isolated antibody

Synonym(s):

PARK2, PRKN, PRKN2, Parkinson disease protein 2, Parkinson juvenile disease protein 2

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About This Item

MDL number:
MFCD02263896
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 51 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

O60260

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PRKN2(5071)

General description

The PRKN (parkin RBR E3 ubiquitin protein ligase) gene, also referred to as PARK2, is mapped to human chromosome 6q25.2–27. It is one of the largest genes in the human genome spanning a length of 1.53Mb. The gene consists of 12 exons and encodes a protein of 465 amino acids. It is broadly expressed in several tissues, including neurons, astrocytes, lung, colon and testes.

Anti-Parkin Antibody detects endogenous levels of total Parkin protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Parkin.

Immunogen Range: 101-150

Biochem/physiol Actions

The PRKN (parkin RBR E3 ubiquitin protein ligase) gene encodes an E3 ubiquitin ligase that is involved in the maintenance of dopamine (DA) neuronal homeostasis. It ubiquitinates target proteins by interacting with ubiquitin-conjugating enzymes, such as UBCH7 (Ubiquitin-conjugating enzyme E2 L3) and UBCH8 (Ubiquitin/ISG15-conjugating enzyme E2 L6). Mutations in this gene have been linked to early-onset and progression of Parkinson′s Disease. Variations in this gene have also been associated with glioblastoma and other human malignancies.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Detection of Parkin (PARK2) and DJ1 (PARK7) mutations in early-onset Parkinson disease: Parkin mutation frequency depends on ethnic origin of patients.
Djarmati A, et al.
Human Mutation, 23(5), 525-525 (2004)
Mutations in PRKN and SNCA genes important for the progress of Parkinson?s disease.
Oczkowska A, et al.
Current Genomics, 14(8), 502-517 (2013)
Parkin genetics: one model for Parkinson's disease.
Mata I F, et al.
Human Molecular Genetics, 13(1), R127-R133 (2004)
Somatic mutations of the Parkinson's disease?associated gene PARK2 in glioblastoma and other human malignancies.
Veeriah S, et al.
Nature Genetics, 42(1), 77-77 (2010)

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