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Key Documents

05-920

Sigma-Aldrich

Anti-NR2B Antibody, clone BWJHL

clone BWJHL, Upstate®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

BWJHL, monoclonal

species reactivity

human, rat

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

mouse ... Grin2B(14812)

Specificity

NR2B

Immunogen

GST fusion protein corresponding to residues 934-1457 of rat NR2B. Clone BWJHL.

Application

Anti-NR2B Antibody, clone BWJHL detects level of NR2B & has been published & validated for use in WB.
Research Category
Neuroscience
Research Sub Category
Neurochemistry & Neurotrophins

Neurodegenerative Diseases

Quality

routinely evaluated by immunoblot on rat brain microsomal preparations (Catalog#12-144)

Target description

Mr 180kDa

Physical form

Format: Purified
Protein G Purified

Storage and Stability

stable 2 years at -20°C from date of shipment

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Brain-derived neurotrophic factor-tyrosine kinase B pathway mediates NMDA receptor NR2B subunit phosphorylation in the supraoptic nuclei following progressive dehydration.
Carre?o, FR; Walch, JD; Dutta, M; Nedungadi, TP; Cunningham, JT
Journal of Neuroendocrinology null
Jackson J Cone et al.
PloS one, 8(3), e58251-e58251 (2013-03-22)
The development of diet-induced obesity (DIO) can potently alter multiple aspects of dopamine signaling, including dopamine transporter (DAT) expression and dopamine reuptake. However, the time-course of diet-induced changes in DAT expression and function and whether such changes are dependent upon
Peter D Cole et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 19(16), 4446-4454 (2013-07-09)
To test whether memantine can prevent methotrexate-induced cognitive deficits in a preclinical model. After noting that methotrexate exposure induces prolonged elevations of the glutamate analog homocysteic acid (HCA) within cerebrospinal fluid, we tested whether intrathecal injection of HCA would produce
Characterization of NMDA receptor subunit-specific antibodies: distribution of NR2A and NR2B receptor subunits in rat brain and ontogenic profile in the cerebellum.
Wang, Y H, et al.
Journal of Neurochemistry, 65, 176-183 (1995)
R A J McIlhinney et al.
Biochemical Society transactions, 31(Pt 4), 865-868 (2003-07-31)
The N-methyl-D-aspartate receptor (NMDAR) requires both NR1 and NR2 subunits to form a functional ion channel. Despite the recent advances in our understanding of the contributions of these different subunits to both the function and pharmacology of the NMDAR, the

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