370656

Guanosine 3′,5′-cyclic Monophosphate, Sodium Salt

Important intracellular second messenger implicated in the action of nitric oxide in many cell types.

• Synonym(s): Guanosine 3′,5′-cyclic Monophosphate, Sodium Salt, Cyclic GMP, G-3,5-MP, cGMP, Na
• Empirical Formula (Hill Notation): C₁₀H₁₁N₅O₇P · Na
• CAS Number: 40732-48-7
• Molecular Weight: 367.19
• MDL number: MFCD00038424
• UNSPSC Code: 41106305
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: >98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
• InChI key: KMPIYXNEROUNOG-GWTDSMLYSA-M

Description

General description

An important intracellular second messenger implicated in mediating the action of nitric oxide in many cell types. Found to activate protein kinase G. Suppresses apoptosis in rat ovarian follicles.

Important intracellular second messenger implicated in the action of nitric oxide in many cell types. Activates protein kinase G. Suppresses apoptosis in rat ovarian follicles.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Activates protein kinase G

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Chun, S.Y., et al. 1995. Endocrinology136, 3120.
Kaupp, U.B., and Koch, K.W. 1992. Annu. Rev. Physiol.54, 153.
Goldberg, N.D., and Haddox, M.K. 1977. Annu. Rev. Biochem. 46, 823.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable