A potent competitive antagonist selective for AMPA/kainate glutamate receptors (IC50 = 0.19-1.66 µM and 0.35 µM for AMPA and GluK2 receptors, respectively). Routinely used as a tool to distinguish the role of neurotransmissions mediated by AMPA/kainate and NMDA receptors in studying brain functions and disorders.
Biochem/physiol Actions
Primary Target AMPA
Secondary Target GluK2
Target IC50: 0.19 to 1.66 uM
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Lee, S., et al. 2010. J. Neurophysiol.103, 1728. Honor, T., et al. 1998. Science.241, 701. Watkins, J., et al. 1990. Adv. Exp. Med. Biol.268, 49. Davies, S., et al. 1990. Int. Rev. Neurobiol.32, 28.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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