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  • Facile preparation of beta-fluoro amines by the reaction of aziridines with potassium fluoride dihydrate in the presence of Bu4NHSO4.

Facile preparation of beta-fluoro amines by the reaction of aziridines with potassium fluoride dihydrate in the presence of Bu4NHSO4.

The Journal of organic chemistry (2004-01-17)
Ren-Hua Fan, Yong-Gui Zhou, Wan-Xuan Zhang, Xue-Long Hou, Li-Xin Dai
ABSTRACT

Potassium fluoride combined with tetrabutylammonium bisulfate is an efficient reagent to convert a variety of aziridines derived from cyclic and acyclic alkenes to beta-fluoro amine derivatives in high yield.

MATERIALS
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Brand
Product Description

Sigma-Aldrich
Tetrabutylammonium bisulfate solution, ~55% in H2O