Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Dalton transactions (Cambridge, England : 2003) (2013-03-27)

George Psomas, Dimitris P Kessissoglou

ABSTRACT

The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.

MATERIALS

Product Number

Brand

Product Description

266655

Sigma-Aldrich

Cobalt, pieces, 99.5% trace metals basis

203076

Sigma-Aldrich

Cobalt, granular, 99.99% trace metals basis

266647

Sigma-Aldrich

Cobalt, powder, <150 μm, ≥99.9% trace metals basis

267074

Sigma-Aldrich

Nickel, rod, diam. 6.35 mm, ≥99.99% trace metals basis

357553

Sigma-Aldrich

Nickel, foil, thickness 0.5 mm, 99.98% trace metals basis

357626

Sigma-Aldrich

Nickel, wire, diam. 0.5 mm, ≥99.9% trace metals basis

356867

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, 99.95% trace metals basis

266639

Sigma-Aldrich

Cobalt, powder, 2 μm particle size, 99.8% trace metals basis

577995

Sigma-Aldrich

Nickel, nanopowder, <100 nm avg. part. size, ≥99% trace metals basis

GF05162217

Nickel, pellets, 50g, max. size 10mm, 99.999%

GF56481969

Nickel, pellets, 20g, max. size 5mm, 99.99+%

GF37939506

Nickel, mesh, 30x30mm, nominal aperture 0.34mm, thickness 0.025mm, wire diameter 0.041mm, 70 wires/inch, open area 80%, electro-formed mesh, 99.9%

GF37018863

Nickel, mesh, 30x30mm, nominal aperture 0.43mm, thickness 0.004mm, wire diameter 0.067mm, 51 wires/inch, open area 75%, electro-formed mesh, 99.9%

GF07235131

Nickel, mesh, 240x240mm, nominal aperture 0.43mm, thickness 0.004mm, wire diameter 0.067mm, 51 wires/inch, open area 75%, electro-formed mesh, 99.9%

GF13212807

Nickel, pellets, 50g, max. size 5mm, 99.99+%

GF60655967

Nickel, pellets, 50g, max. size 10mm, 99.99+%

GF00192327

Nickel, insulated wire, 20m, conductor diameter 0.025mm, insulation thickness 0.0035mm, polyimide insulation

GF10370618

Nickel, mesh, 30x30mm, nominal aperture 0.04mm, thickness 0.004mm, wire diameter 0.011mm, 500 wires/inch, open area 60%, electro-formed mesh, 99.9%

GF12092778

Nickel, pellets, 20g, max. size 20mm, 99.99+%

GF53673992

Nickel, pellets, 50g, max. size 20mm, 99.99+%

GF02217394

Nickel, pellets, 20g, max. size 10mm, 99.999%

GF33408648

Nickel, broken cathode squares, 200g, max. size 50mm, 99.8%

267058

Sigma-Aldrich

Nickel, wire, diam. 0.5 mm, ≥99.99% trace metals basis

267007

Sigma-Aldrich

Nickel, foil, thickness 0.25 mm, 99.995% trace metals basis

510033

Sigma-Aldrich

Raney^®-Nickel, W.R. Grace and Co. Raney^® 2400, slurry, in H₂O, active catalyst

203904

Sigma-Aldrich

Nickel, powder, <150 μm, 99.99% trace metals basis

GF01449053

Nickel, pellets, 50g, max. size 15mm, 99.99+%

GF35122092

Nickel, mesh, 65x65mm, nominal aperture 0.04mm, thickness 0.004mm, wire diameter 0.011mm, 500 wires/inch, open area 60%, electro-formed mesh, 99.9%

GF11350381

Nickel, pellets, 100g, max. size 20mm, 99.99+%

GF19857864

Nickel, insulated wire, 2m, conductor diameter 0.025mm, insulation thickness 0.0035mm, polyimide insulation