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Quantification of chemical elements in blood of patients affected by multiple sclerosis.

Quantification of chemical elements in blood of patients affected by multiple sclerosis.

Annali dell'Istituto superiore di sanita (2005-10-26)

Giovanni Forte, Andrea Visconti, Simone Santucci, Anna Ghazaryan, Lorenzo Figà-Talamanca, Stefania Cannoni, Beatrice Bocca, Anna Pino, Nicola Violante, Alessandro Alimonti, Marco Salvetti, Giovanni Ristori

ABSTRACT

Although some studies suggested a link between exposure to trace elements and development of multiple sclerosis (MS), clear information on their role in the aetiology of MS is still lacking. In this study the concentrations of Al, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Ni, Pb, Sb, Si, Sn, Sr, Tl, V, W, Zn and Zr were determined in the blood of 60 patients with MS and 60 controls. Quantifications were performed by inductively coupled plasma (ICP) atomic emission spectrometry and sector field ICP mass spectrometry. When the two groups were compared, an increased level of Co, Cu and Ni and a decrement of Be, Fe, Hg, Mg, Mo, Pb and Zn in blood of patients were observed. In addition, the discriminant analysis pointed out that Cu, Be, Hg, Co and Mo were able to discriminate between MS patients and controls (92.5% of cases correctly classified).

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Aluminum, wire, diam. 0.58 mm, ≥99.99% trace metals basis

Sigma-Aldrich

Magnesium, in a Sure/Seal^™ bottle, turnings, 37.5 mmol

Sigma-Aldrich

Titanium, 5-10 mm, ≥99.99% trace metals basis (purity exclusive of Na and K content)

Sigma-Aldrich

Titanium, wire, diam. 0.25 mm, 99.7% trace metals basis

Sigma-Aldrich

Cobalt, powder, <150 μm, ≥99.9% trace metals basis

Sigma-Aldrich

Titanium, wire, diam. 0.81 mm, 99.7% trace metals basis

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, 99.95% trace metals basis

Sigma-Aldrich

Vanadium, powder, −325 mesh, 99.5% trace metals basis

Sigma-Aldrich

Zinc, pieces, 2-14 mesh, 99.9% trace metals basis

Sigma-Aldrich

Magnesium, ReagentPlus^®, ribbon, ≥99% trace metals basis

Sigma-Aldrich

Tin, granular, 0.425-2.0 mm particle size, ≥99.5%, ACS reagent

Sigma-Aldrich

Tungsten, foil, thickness 0.25 mm, ≥99.9% trace metals basis

Sigma-Aldrich

Aluminum, powder, ≥91% (complexometric)

Continuous cast copper (O), BCR^®, certified reference material, rod

Sigma-Aldrich

Zinc, shot, <12 mm, 99.99% trace metals basis

Sigma-Aldrich

Chromium, powder, 99.5%, −100 mesh

Sigma-Aldrich

Copper, powder, <75 μm, 99%

Sigma-Aldrich

Titanium, foil, thickness 0.025 mm, 99.98% trace metals basis

Sigma-Aldrich

Acetic acid, natural, ≥99.5%, FG

Sigma-Aldrich

Magnesium, turnings, reagent grade, 98%

Sigma-Aldrich

Magnesium, dendritic pieces, purified by distillation, 99.998% trace metals basis

Sigma-Aldrich

Zinc, dust, <10 μm, ≥98%

Sigma-Aldrich

Titanium, foil, thickness 0.127 mm, 99.7% trace metals basis

Sigma-Aldrich

Chromium, chips, 99.995% trace metals basis

Sigma-Aldrich

Strontium, dendritic pieces, purified by distillation, 99.99% trace metals basis

Sigma-Aldrich

Vanadium, foil, thickness 0.127 mm, 99.7% trace metals basis

Sigma-Aldrich

Magnesium, turnings, 5-25 mm, 99.95% trace metals basis

Sigma-Aldrich

Strontium, granular, 99% trace metals basis

Sigma-Aldrich

Manganese, powder, ≥99.9% trace metals basis

Supelco

Acetic acid, analytical standard