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  • Enhanced photochemical [6π] electrocyclization within the lipophilic protein binding site.

Enhanced photochemical [6π] electrocyclization within the lipophilic protein binding site.

Organic letters (2012-03-16)
Mireia Marin, Virginie Lhiaubet-Vallet, Miguel A Miranda
PMID22416929
ABSTRACT

Photocyclization of N-methyldiphenylamine to N-methylcarbazole is achieved within the microenvironment provided by site I of serum albumins. Quantum yield determinations, combined with transient absorption spectroscopic detection of the dihydrocarbazole intermediate, demonstrate that protein encapsulation provides a subtle control of the kinetic parameters, leading to optimized efficiencies.