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  • Organosilicon compounds as adult T-cell leukemia cell proliferation inhibitors.

Organosilicon compounds as adult T-cell leukemia cell proliferation inhibitors.

Chemical & pharmaceutical bulletin (2013-02-02)
Masaharu Nakamura, Yotaro Matsumoto, Masaaki Toyama, Masanori Baba, Yuichi Hashimoto
ABSTRACT

Aggressive forms of adult T-cell leukemia (ATL) respond poorly to conventional anticancer chemotherapy, and new lead compounds are required for the development of drugs to treat this fatal disease. Recently, we developed ATL cell-selective proliferation inhibitors based on a tetrahydrotetramethylnaphthalene (TMN) skeleton 1, and here we report the design and synthesis of silicon analogs of TMN derivatives. Among them, compound 13 showed the most potent growth-inhibitory activity towards the ATL cell line S1T, though its selectivity for S1T over the non-ATL cell line MOLT-4 was only moderate. This result, as well as computational studies, suggests that sila-substitution (C/Si exchange) is useful for structure optimization of these inhibitors.

MATERIALS
Product Number
Brand
Product Description

Supelco
Naphthalene solution, certified reference material, 5000 μg/mL in methanol