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  • The identification of perillyl alcohol glycosides with improved antiproliferative activity.

The identification of perillyl alcohol glycosides with improved antiproliferative activity.

Journal of medicinal chemistry (2014-08-15)
Nitin S Nandurkar, Jianjun Zhang, Qing Ye, Larissa V Ponomareva, Qing-Bai She, Jon S Thorson
PMID25121720
ABSTRACT

A facile route to perillyl alcohol (POH) differential glycosylation and the corresponding synthesis of a set of 34 POH glycosides is reported. Subsequent in vitro studies revealed a sugar dependent antiproliferative activity and the inhibition of S6 ribosomal protein phosphorylation as a putative mechanism of representative POH glycosides. The most active glycoside from this cumulative study (4'-azido-d-glucoside, PG9) represents one of the most cytotoxic POH analogues reported to date.