Skip to Content
Merck
All Photos(1)

Documents

SRP6561

Sigma-Aldrich

Cathepsin K Active human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(s):

CTSK, CTSO, CTSO3

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

form

liquid

mol wt

23.5 kDa (115-329 aa)

packaging

pkg of 5 μg
pkg of 50 μg

concentration

0.5 mg/mL

technique(s)

activity assay: suitable

suitability

suitable for molecular biology

UniProt accession no.

P43235

application(s)

life science and biopharma

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CTSK(1513)

General description

Cathepsin K is expressed as procathepsin K, which is the inactive proenzyme of cathepsin K. Cathepsin K is a lysosomal cysteine protease and part of the papain cysteine protease family. It is expressed in osteoclasts. The gene encoding this protein is localized on human chromosome 1q21.

Biochem/physiol Actions

Cathepsin K has a role in bone resorption and remodeling. It has a triple helical collagen hydrolase activity. Mutations in the gene encoding this protein have been linked to pycnodysostosis.

Physical form

0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Cathepsin K as a biomarker of bone involvement in type 1 Gaucher disease.
Bobillo L J, et al.
Medicina clinica, 145(7), 281-287 (2015)
Increased Circulating Cathepsin K in Patients with Chronic Heart Failure.
Zhao G, et al.
PLoS ONE, 10(8), e0136093-e0136093 (2015)
Andrew Wieczorek et al.
BMC biotechnology, 15, 112-112 (2015-12-17)
Triple helical collagens are the most abundant structural protein in vertebrates and are widely used as biomaterials for a variety of applications including drug delivery and cellular and tissue engineering. In these applications, the mechanics of this hierarchically structured protein
A Mutation in CTSK Gene in an Autosomal Recessive Pycnodysostosis Family of Chinese Origin.
Huang X, et al.
Calcified Tissue International, 96(5), 373-378 (2015)
Autocatalytic activation of human cathepsin K.
McQueney M S, et al.
The Journal of Biological Chemistry, 272(21), 13955-13960 (1997)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service