N6909

Neurturin human

>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

• Synonym(s): NRTN, NTN
• MDL number: MFCD01867712
• UNSPSC Code: 51111800

Properties

• biological source: human
• recombinant: expressed in E. coli
• Assay: >95% (SDS-PAGE)
• form: lyophilized powder
• potency: 15-50 ng/mL ED₅₀
• mol wt: monomer calculated mol wt ~12.5 kDa; predicted mol wt ~14 kDa by SDS-PAGE (reducing)
• storage condition: avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
• impurities: endotoxin, tested
• UniProt accession no.: Q99748
• storage temp.: −20°C
• Gene Information: human ... NRTN(4902)

Description

Biochem/physiol Actions

Member of the glial cell line-derived neurotrophic factor family of ligands. Exerts potent effects on the function and survival of central and peripheral neurons. Activates the RET receptor tyrosine kinase, MAP kinase, and phosphatidylinositol 3-kinase pathways. Human and mouse NTN share 91% sequence identity.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to bind recombinant human GFRα2/Fc.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves