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Merck

KIR2DL5A

killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A

Synonyms:
CD158F, KIR2DL5, KIR2DL5.1, KIR2DL5.3, KIR2DL5B
Species:
Human KIR2DL5A (57292), cow KIR2DL5A (282860)
UniProtKB ID:
Q8N109
Gene ID:
  • Human(57292) Summary: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
  • cow(282860) killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB1401781
Anti-KIR2DL5A antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
SAB1409553
Anti-KIR2DL5A antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
SAB4701137
Monoclonal Anti-CD158f-APC antibody produced in mouse, clone UP-R1,
Species Reactivity
Application
flow cytometry
SAB4700915
Monoclonal Anti-CD158f antibody produced in mouse, clone UP-R1,
Species Reactivity
human
Application
flow cytometry