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DRD3

dopamine receptor D3

Synonyms:

D3DR, ETM1, FET1

Species:

Human DRD3 (1814), Mouse Drd3 (13490), Rat Drd3 (29238), Zebrafish drd3 (282554), chicken DRD3 (770757), Horse DRD3 (100061160), domestic cat DRD3 (101092878), dog DRD3 (487984), sheep DRD3 (101103110), cow DRD3 (537043) ...More

UniProtKB ID:

P35462, A1A4V5, Q4VBM8

Gene ID:

Human(1814) Summary: This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Mouse(13490) dopamine receptor D3
Rat(29238) dopamine receptor D3
Zebrafish(282554) dopamine receptor D3
chicken(770757) dopamine receptor D3
Horse(100061160) dopamine receptor D3
domestic cat(101092878) dopamine receptor D3
dog(487984) dopamine receptor D3
sheep(101103110) dopamine receptor D3
cow(537043) dopamine receptor D3
naked mole-rat(101713857) dopamine receptor D3
domestic guinea pig(100716075) dopamine receptor D3

Products (95)
Peer Reviewed Papers (221)

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Small Molecule - Agonist

Product Number

Description

Species

Levodopa, British Pharmacopoeia (BP) Reference Standard,

Species

human

Levodopa, European Pharmacopoeia (EP) Reference Standard,

Species

human

Levodopa, Pharmaceutical Secondary Standard; Certified Reference Material,

Species

human

(±)-7-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide, ,

Species

human

Piribedil maleate salt, ,

Species

human

Small Molecule - Antagonist

Product Number

Description

Species

U116

U-99194 maleate salt, ≥98% (HPLC), solid,

Species

human

Oxatomide, ≥99%,

Species

human

L135

L-741,626, ≥98% (HPLC),

Species

human

Chlorpromazine hydrochloride, VETRANAL^®, analytical standard,

Species

human

Promazine hydrochloride, VETRANAL^®, analytical standard,

Species

human

Antibodies

Product Number

Description

Species Reactivity

Application

Anti-Dopamine Receptor D3 (DRD3) Antibody, clone 5L1P4, Rabbit Monoclonal, ,

Species Reactivity

human, rat

Application

western blot

Anti-Dopamine D3 Receptor Antibody, cytoplasmic domain, Chemicon^®, from rabbit,

Species Reactivity

human

Application

ELISA
immunohistochemistry
western blot

Anti-DRD3 / DOPAMINE antibody produced in rabbit, affinity isolated antibody,

Species Reactivity

dog, hamster, horse, human, monkey, mouse, pig

Application

immunohistochemistry

Anti-Dopamine D3 Receptor Antibody, cytoplasmic domain, Chemicon^®, from rabbit,

Species Reactivity

mouse, rat

Application

ELISA
immunohistochemistry
western blot

Anti-Dopamine D₃ Receptor Rabbit pAb, lyophilized, Calbiochem^®,

Species Reactivity

human, rat

Application

Small Molecule - Inhibitor

Product Number

Description

Species

2-Bromo-α-ergocryptine methanesulfonate salt, solid,

Species

human

D052

GBR 12909 dihydrochloride, solid, ≥98% (HPLC),

Species

human

B102

Bupropion hydrochloride, ≥98% (HPLC), solid,

Species

human

Amoxapine, Pharmaceutical Secondary Standard; Certified Reference Material,

Species

human

Amoxapine, 1.0 mg/mL in methanol, certified reference material, Cerilliant^®,

Species

human

Small Molecule - Metabolite

Product Number

Description

Species

3-Hydroxy-4-methoxyphenethylamine hydrochloride, ,

Species

human

3-Methoxytyramine hydrochloride, ≥95.5%, crystalline,

Species

human

Small Molecule - Mixed Agonist/Antagonist

Product Number

Description

Species

BP897, >98% (HPLC), solid,

Species

human, rat

Haloperidol, powder,

Species

human, rat

Clozapine, ,

Species

human, rat

Small Molecule - Precursor

Product Number

Description

Species

3,4-Dihydroxy-DL-phenylalanine, ,

Species

mouse, human, rat

3,4-Dihydroxy-L-phenylalanine, ≥98% (TLC),

Species

mouse, human, rat

Proteins

Product Number

Description

Species

D181

D₃ Dopamine Receptor from rat, recombinant, expressed in E. coli, membrane suspension,

Species

rat

esiRNA

Product Number

Description

Species

MISSION^® esiRNA, targeting human DRD3,

Species

human