Porous silicon advances in drug delivery and immunotherapy.

Porous silicon advances in drug delivery and immunotherapy.

Current opinion in pharmacology (2013-07-13)

David J Savage, Xuewu Liu, Steven A Curley, Mauro Ferrari, Rita E Serda

ABSTRACT

Biomedical applications of porous silicon include drug delivery, imaging, diagnostics and immunotherapy. This review summarizes new silicon particle fabrication techniques, dynamics of cellular transport, advances in the multistage vector approach to drug delivery, and the use of porous silicon as immune adjuvants. Recent findings support superior therapeutic efficacy of the multistage vector approach over single particle drug delivery systems in mouse models of ovarian and breast cancer. With respect to vaccine development, multivalent presentation of pathogen-associated molecular patterns on the particle surface creates powerful platforms for immunotherapy, with the porous matrix able to carry both antigens and immune modulators.

MATERIALS

Product Number

Brand

Product Description

343250

Sigma-Aldrich

Silicon, pieces, 99.95% trace metals basis

215619

Sigma-Aldrich

Silicon, powder, −325 mesh, 99% trace metals basis

633097

Sigma-Aldrich

Silicon, nanopowder, <100 nm particle size (TEM), ≥98% trace metals basis

647705

Sigma-Aldrich

Silicon, wafer, <111>, P-type, contains boron as dopant, diam. × thickness 2 in. × 0.3 mm

647101

Sigma-Aldrich

Silicon, wafer (single side polished), <111>, N-type, contains no dopant, diam. × thickness 2 in. × 0.5 mm

647543

Sigma-Aldrich

Silicon, wafer (single side polished), <111>, N-type, contains no dopant, diam. × thickness 3 in. × 0.5 mm

647535

Sigma-Aldrich

Silicon, wafer (single side polished), <100>, N-type, contains no dopant, diam. × thickness 3 in. × 0.5 mm

647780

Sigma-Aldrich

Silicon, wafer (single side polished), <100>, N-type, contains phosphorus as dopant, diam. × thickness 2 in. × 0.5 mm

647799

Sigma-Aldrich

Silicon, wafer (single side polished), <111>, N-type, contains phosphorus as dopant, diam. × thickness 2 in. × 0.5 mm

647772

Sigma-Aldrich

Silicon, wafer (single side polished), <111>, P-type, contains boron as dopant, diam. × thickness 3 in. × 0.5 mm

646687

Sigma-Aldrich

Silicon, wafer (single side polished), <100>, N-type, contains no dopant, diam. × thickness 2 in. × 0.5 mm

647675

Sigma-Aldrich

Silicon, wafer (single side polished), <100>, P-type, contains boron as dopant, diam. × thickness 2 in. × 0.5 mm

647802

Sigma-Aldrich

Silicon, wafer (single side polished), <100>, N-type, contains phosphorus as dopant, diam. × thickness 3 in. × 0.5 mm

647764

Sigma-Aldrich

Silicon, wafer (single side polished), <100>, P-type, contains boron as dopant, diam. × thickness 3 in. × 0.5 mm

GF46268433

Silicon, disks, 15.9mm, thickness 0.38mm, single crystal, n-type, 100%

GF16286227

Silicon, disks, 15.9mm, thickness 0.38mm, single crystal, n-type, 100%

GF37993595

Silicon, rod, 100mm, diameter 10.0mm, single crystal - random orientation, 100%

GF84708681

Silicon, rod, 100mm, diameter 12.7mm, single crystal - random orientation, 100%

GF64686998

Silicon, rod, 100mm, diameter 2.0mm, crystalline, 100%

GF04814951

Silicon, rod, 100mm, diameter 25mm, crystalline, 100%

GF28448691

Silicon, rod, 50mm, diameter 5mm, single crystal, -100, 99.999%

GF22929307

Silicon, rod, 100mm, diameter 5.0mm, crystalline, 100%

GF20311254

Silicon, sheet, 25x25mm, thickness 1.0mm, polycrystalline, 99.999%

GF43555664

Silicon, rod, 25mm, diameter 3.15mm, single crystal - random orientation, 100%

GF41762493

Silicon, sheet, 25x25mm, thickness 1.0mm, single crystal, -100, 100%

GF73529051

Silicon, sheet, 52x52mm, thickness 1.0mm, polycrystalline, 99.999%

GF16363391

Silicon, rod, 10mm, diameter 2.0mm, crystalline, 100%

GF64342188

Silicon, rod, 50mm, diameter 6mm, single crystal, -111, 99.999%

GF85621923

Silicon, sheet, 40x40mm, thickness 3.0mm, single crystal, p-type, 100%

GF40945754

Silicon, rod, 50mm, diameter 5mm, single crystal, -111, 99.999%