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Merck

Liquid phase ion mobility spectrometry.

The Analyst (2011-06-24)
Maggie Tam, Herbert H Hill
ABSTRACT

A novel analytical method, called Liquid Phase Ion Mobility Spectrometry (LiPIMS) was demonstrated, where aqueous phase analytes were ionized and introduced into non-aqueous liquids, transported by an external electric field from the point of generation to a collection electrode. Ions were produced from a unique liquid phase ionization process, called Electrodispersion Ionization. Spectra of analyte ions illustrated the potential of LiPIMS as a new separation technique. Experimental data showed that electrodispersion ionization was effective in generating nanoampere level of ion current in hexane and benzene from aqueous samples. By controlling the ionization voltage in relation to the sample flow rate, it was possible to operate the electrodispersion ionization source in both continuous and pulsed ionization modes. Unique LiPIMS spectra of aqueous samples of tetramethylammonium bromide, tetrabutylammonium bromide and bradykinin were presented and their respected liquid phase ion mobility values were determined.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Tetramethylammonium hydroxide solution, 10 wt. % in H2O
Sigma-Aldrich
Tetramethylammonium hydroxide solution, 25 wt. % in methanol
Supelco
Tetramethylammonium chloride, suitable for ion pair chromatography, LiChropur, ≥99.0% (AT)
Sigma-Aldrich
Tetramethylammonium hydroxide solution, ACS reagent
Sigma-Aldrich
Tetramethylammonium fluoride, 97%
Supelco
Tetramethylammonium sulfate, suitable for ion pair chromatography, LiChropur, ≥99.0% (T)
Sigma-Aldrich
Tetramethylammonium chloride, reagent grade, ≥98%
Sigma-Aldrich
Tetramethylammonium chloride, BioUltra, for molecular biology, ≥99.0% (AT)
Sigma-Aldrich
Tetramethylammonium hydroxide solution, 25 wt. % in H2O
Supelco
Tetramethylammonium bromide, suitable for ion pair chromatography, LiChropur, ≥99.0% (AT)
Sigma-Aldrich
Tetramethylammonium hydroxide pentahydrate, ≥95.0% (T)
Sigma-Aldrich
Tetramethylammonium bromide, ACS reagent, ≥98.0%
Sigma-Aldrich
Tetramethylammonium hydroxide pentahydrate, ≥97%
Sigma-Aldrich
Tetramethylammonium bromide, 98%
Sigma-Aldrich
Tetramethylammonium chloride solution, for molecular biology
Sigma-Aldrich
Tetramethylammonium iodide, 99%