D6946

(R)-DRF053 hydrochloride hydrate

≥98% (HPLC)

• Synonym(s): 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]- 9H-purin-2-yl]amino]-1-butanol hydrochloride hydrate
• Empirical Formula (Hill Notation): C₂₃H₂₇N₇O · xHCl · yH₂O
• Molecular Weight: 417.51 (anhydrous free base basis)
• MDL number: MFCD17215921
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798839
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: yellow
• solubility: DMSO: ≥30 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.Cl.CC[C@H](CO)Nc1nc(Nc2cccc(c2)-c3ccccn3)c4ncn(C(C)C)c4n1
• InChI: 1S/C23H27N7O.ClH.H2O/c1-4-17(13-31)27-23-28-21(20-22(29-23)30(14-25-20)15(2)3)26-18-9-7-8-16(12-18)19-10-5-6-11-24-19;;/h5-12,14-15,17,31H,4,13H2,1-3H3,(H2,26,27,28,29);1H;1H2/t17-;;/m1../s1
• InChI key: ZOSNTFVWVJFXQO-ZEECNFPPSA-N

Description

Biochem/physiol Actions

DRF053 is a more potent version of roscovitine. It is 2 fold more potent against CDK5 (80 nM) and over 150 times more potent against CDK1 (14 nM).

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable