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457M-9

Sigma-Aldrich

p57Kip2 (Kp10) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

Kp10, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (457M-94)
vial of 0.5 mL concentrate (457M-95)
bottle of 1.0 mL predilute (457M-97)
vial of 1.0 mL concentrate (457M-96)
bottle of 7.0 mL predilute (457M-98)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG2bκ

control

placenta

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... CDKN1C(1028)

Related Categories

General description

Anti-p57 has been used as an aid in discriminating complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts or stromal cells) from partial hydatidiform mole (PHM) (nuclear staining of both cytotrophoblasts and stromal cells) and hydropic abortion. In normal placenta, cytotrophoblast, syncytio trophoblast, and stromal cells are labeled with this antibody. Intervillous trophoblastic islands demonstrate nuclear labeling in all entities and serve as an internal control.
p57 is a human tumor suppressor gene encoded on the 11p15.5 chromosomal sequence. Anti-p57 has been used as an aid in discriminating complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts or stromal cells) from partial hydatidiform mole (PHM) (nuclear staining of both cytotrophoblasts and stromal cells) and hydropic abortion. In the normal placenta, cytotrophoblast, intermediate trophoblast and decidual cells, and stromal cells are labeled with this antibody. Intervillous trophoblastic islands demonstrate nuclear labeling in all entities and serve as an internal control.

Quality


IVD
IVD
IVD
RUO

Linkage

P57Kip2 Positive Control Slides, Product No. 457S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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Maki Kihara et al.
The Journal of reproductive medicine, 50(5), 307-312 (2005-06-24)
To evaluate whether p57KIP2 expression is concordant with the result of DNA polymorphism analysis in molar pregnancy. Eleven molar pregnancies diagnosed by pathologic findings between October 2002 and April 2004 were studied. Histopathologic diagnosis, DNA polymorphism analysis and p57KIP2 immunohistochemistry
Veli-Matti Marjoniemi
Pathology, 36(2), 109-119 (2004-06-19)
This paper reviews some aspects of the application of immunohistochemistry in gynaecological pathology. The use of cytokeratins 7 and 20 are discussed with reference to applications in ovarian pathology, including metastatic disease to the ovaries. Developments in utilising MIB-1 and
S-Y Jun et al.
Histopathology, 43(1), 17-25 (2003-06-26)
To determine the utility of p57kip2 in the diagnosis of hydatidiform mole. p57kip2 protein is a cyclin-dependent kinase inhibitor (CDKI) and is strongly paternally imprinted, being expressed from the maternal allele. It has been hypothesized that complete mole (CHM) with
Rita L Romaguera et al.
Fetal and pediatric pathology, 23(2-3), 181-190 (2005-03-17)
Classification of molar gestations into complete and partial and their differentiation from hydropic abortions traditionally are accomplished by morphology alone. The process sometimes may be inaccurate or inconclusive. With the availability of p57 immunostaining it may be possible to objectively

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