125660

Leucomalachite Green

powder

• Synonym(s): 4,4′-Benzylidenebis(N,N-dimethylaniline)
• Linear Formula: C₆H₅CH[C₆H₄N(CH₃)₂]₂
• CAS Number: 129-73-7
• Molecular Weight: 330.47
• Beilstein: 2140506
• EC Number: 204-961-9
• MDL number: MFCD00008315
• UNSPSC Code: 12171500
• PubChem Substance ID: 24847677
• NACRES: NA.47

Properties

• form: powder
• Quality Level: 100
• mp: 100-102 °C (lit.)
• λmax: 623 nm
• application(s): diagnostic assay manufacturing; hematology; histology
• storage temp.: room temp
• SMILES string: CN(C)c1ccc(cc1)C(c2ccccc2)c3ccc(cc3)N(C)C
• InChI: 1S/C23H26N2/c1-24(2)21-14-10-19(11-15-21)23(18-8-6-5-7-9-18)20-12-16-22(17-13-20)25(3)4/h5-17,23H,1-4H3
• InChI key: WZKXBGJNNCGHIC-UHFFFAOYSA-N

Description

Application

Leucomalachite green has been used as a reagent in presumptive tests which are used to detect invisible blood stains.

Biochem/physiol Actions

Leucomalachite green (LMG) is a chief metabolite of malachite green, a triphenylmethane dye that has been used generally as an antifungal drug in the fish industry. DNA adducts formed in livers of rats fed with leucomalachite green have been observed with little mutagenic or carcinogenic effect. LMG is one of the most commonly used reagents for presumptive blood test. It gives a characteristic green color in the presence of blood. LMG destroys DNA in the blood, therefore, the chances of DNA recovery and amplification is reduced or eliminated.

Safety Information

• Pictograms: GHS08,GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H302,H341,H351,H410
• Precautionary Statements: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Muta. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves