559393-M

SB 202190, Hydrochloride

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190.

• Synonym(s): SB 202190, Hydrochloride, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride
• Empirical Formula (Hill Notation): C₂₀H₁₄FN₃O · xHCl
• CAS Number: 350228-36-3
• Molecular Weight: 331.34 (free base basis)
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: solid
• potency: 16 nM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: amber
• solubility: water: 0.5 mg/mL (slightly soluble); DMSO: soluble
• storage temp.: −20°C
• InChI: 1S/C20H14FN3O.ClH/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15;/h1-12,25H,(H,23,24);1H
• InChI key: XOQSUTIMRLPFPB-UHFFFAOYSA-N

Description

General description

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).

Biochem/physiol Actions

Target IC₅₀: 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable