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  • Optimizing treatment of the partially platinum-sensitive ovarian cancer patient.

Optimizing treatment of the partially platinum-sensitive ovarian cancer patient.

Future oncology (London, England) (2013-11-15)
Nicoletta Colombo
ABSTRACT

Ovarian cancer is the leading cause of gynecological cancer deaths worldwide. Despite primary treatment with platinum-containing regimens, the majority of women will experience recurrent disease and subsequent death. Recurrent ovarian cancer remains a challenge for successful management, and the choice of second-line chemotherapy is complex due to the range of different factors that need to be considered. One of the main considerations is the platinum-free interval and, specifically, the optimal treatment for patients who are partially platinum-sensitive (platinum-free interval: 6-12 months). Data from the large, multicenter, randomized OVA-301 study have shown that combined trabectedin-pegylated liposomal doxorubicin (PLD) significantly prolonged median overall survival compared with PLD alone (p = 0.0027) in 214 patients with partially platinum-sensitive advanced relapsed ovarian cancer. Furthermore, in OVA-301 patients with partially platinum-sensitive disease who received platinum therapy immediately after disease progression (n = 94), final median overall survival was improved by 9 months (p = 0.0153) in trabectedin-PLD patients compared with PLD alone. In addition to demonstrating a survival advantage, trabectedin-PLD may also allow the treatment of patients having not yet recovered from previous platinum toxicity. In summary, the data suggest the use of combined trabectedin-PLD as a second-line treatment option in patients with partially platinum-sensitive recurrent ovarian cancer, followed by a third-line platinum-containing regimen.

MATERIALS
Product Number
Brand
Product Description

Platinum, foil, not light tested, 50x50mm, thickness 0.004mm, as rolled, 99.95%
Platinum, tube, 100mm, outside diameter 3.0mm, inside diameter 2.8mm, wall thickness 0.1mm, as drawn, 99.95%
Platinum, insulated wire, 2m, conductor diameter 0.018mm, insulation thickness 0.002mm, polyester insulation, 99.99%
Platinum, rod, 2mm, diameter 2.0mm, 99.95%
Platinum, tube, 100mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%
Platinum, rod, 10mm, diameter 4.0mm, 99.95%
Platinum, insulated wire, 0.5m, conductor diameter 0.05mm, insulation thickness 0.0075mm, polyester insulation, 99.99%
Platinum, insulated wire, 5m, conductor diameter 0.05mm, insulation thickness 0.009mm, PTFE (polytetrafluoroethylene) insulation, 99.99%
Platinum, tube, 200mm, outside diameter 0.95mm, inside diameter 0.60mm, wall thickness 0.175mm, as drawn, 99.95%
Platinum, foil, not light tested, 50x50mm, thickness 0.01mm, as rolled, 99.95%
Platinum, insulated wire, 1m, conductor diameter 0.05mm, insulation thickness 0.009mm, PTFE (polytetrafluoroethylene) insulation, 99.99%
Platinum, foil, 30x30mm, thickness 0.2mm, as rolled, 99.95%
Platinum, foil, 15x15mm, thickness 0.2mm, as rolled, 99.95%
Platinum, rod, 10mm, diameter 5.0mm, 99.95%
Platinum, tube, 200mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%
Platinum, tube, 100mm, outside diameter 0.6mm, inside diameter 0.5mm, wall thickness 0.05mm, as drawn, 99.95%
Platinum, rod, 50mm, diameter 1.25mm, 99.95%
Platinum, insulated wire, 2m, conductor diameter 0.025mm, insulation thickness 0.001mm, PTFE (polytetrafluoroethylene) insulation, 99.999%
Platinum, tube, 1000mm, outside diameter 0.6mm, inside diameter 0.5mm, wall thickness 0.05mm, as drawn, 99.95%
Platinum, insulated wire, 5m, conductor diameter 0.025mm, insulation thickness 0.005mm, polyester insulation, 99.99%
Platinum, rod, 200mm, diameter 1.0mm, 99.95%
Platinum, foil, 25x25mm, thickness 0.25mm, as rolled, 99.99+%
Platinum, tube, 50mm, outside diameter 1.0mm, inside diameter 0.8mm, wall thickness 0.1mm, as drawn, 99.95%
Platinum, foil, 25x25mm, thickness 0.125mm, as rolled, 99.99+%
Platinum, wire reel, 0.05m, diameter 1.0mm, as drawn, 99.99+%
Platinum, foil, not light tested, 50x50mm, thickness 0.0025mm, as rolled, 99.95%
Platinum, microfoil, disks, 25mm, thinness 0.1μm, specific density 120μg/cm2, permanent mylar 3.5μm support, 99.99%
Platinum, insulated wire, 0.2m, conductor diameter 0.125mm, insulation thickness 0.014mm, polyester insulation, 99.99%
Platinum, wire reel, 0.05m, diameter 0.175mm, as drawn, 99.95%
Platinum, rod, 25mm, diameter 1.0mm, 99.95%