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  • Dinitrotoluene exposure in the copper mining industry and renal cancer: a case-cohort study.

Dinitrotoluene exposure in the copper mining industry and renal cancer: a case-cohort study.

Occupational and environmental medicine (2014-02-04)
Andreas Seidler, Volker Harth, Dirk Taeger, Matthias Möhner, Katarzyna Gawrych, Annekatrin Bergmann, Johannes Haerting, Hans-Joachim Kahmann, Hermann Maximilian Bolt, Kurt Straif, Thomas Brüning
ABSTRACT

To evaluate the association between dinitrotoluene (DNT) exposure and renal cancer in a case-cohort study. This case-cohort study was conducted among men born between 1920 and 1974 (n=16 441) who were gainfully employed between 1953 and 1990 in one of two copper mines in Mansfeld, Saxony-Anhalt, former German Democratic Republic, and followed up till 31 December 2006. The study included 109 cases with renal cancer identified by record linkage with the Common Cancer Registry of the New Federal States of Germany (GKR) or by a network of pathology institutes. A comparison subcohort of 999 cohort members was selected at random from the total cohort. Duration and intensity of inhalation and dermal exposure to DNT were assessed on the basis of a job exposure matrix. A time-dependent Cox proportional hazards model modified for case-cohort design was used to assess the relationship between cumulative inhalation and dermal DNT exposure and renal cancer. Elevated risks were found for medium (HR=2.73; 95% CI 1.00 to 7.42) and high (HR=1.81; 95% CI 0.75 to 4.33) dermal exposure to DNT. Relative risks for medium inhalation exposure to DNT were not increased (HR=0.93; 95% CI 0.48 to 1.79) while relative risks for high inhalation exposure to DNT were elevated to 1.36 (95% CI 0.84 to 2.21). We found a statistically significant HR of 2.12 (95% CI 1.03 to 4.37) for combined medium or high inhalation and medium or high dermal exposure to DNT. According to our case-cohort study, dermal and inhalation exposure to DNT is associated with increased renal cancer risk.

MATERIALS
Product Number
Brand
Product Description

Supelco
Toluene solution, certified reference material, 5000 μg/mL in methanol
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Toluene solution, certified reference material, TraceCERT®, 200 μg/mL in methanol, ampule of 1 mL
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Toluene, anhydrous, 99.8%
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Toluene, HPLC Plus, for HPLC, GC, and residue analysis, ≥99.9%
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Toluene, Pharmaceutical Secondary Standard; Certified Reference Material
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Toluene, ACS reagent, ≥99.5%
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Residual Solvent - Toluene, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Toluene, ACS reagent, ≥99.5%
Sigma-Aldrich
Toluene, ACS reagent, ≥99.5%