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  • Rhodium-catalysed asymmetric hydrogenation as a valuable synthetic tool for the preparation of chiral drugs.

Rhodium-catalysed asymmetric hydrogenation as a valuable synthetic tool for the preparation of chiral drugs.

Chemical Society reviews (2012-11-08)
Pablo Etayo, Anton Vidal-Ferran
ABSTRACT

During the last few decades, rhodium-catalysed asymmetric hydrogenation of diverse alkene classes has emerged as a powerful synthetic tool in the pharmaceutical industry, contributing to the manufacturing of chiral drugs, recent drug candidates for clinical trials, and major synthetic precursors of drugs. Numerous efficient chiral rhodium complexes, most of which are derived from enantiopure phosphorus ligands, have been employed for the preparation of chiral drugs and intermediates thereof. This review article is intended to provide an updated overview of the most striking contributions in this field, organised according to substrate class: acrylate derivatives, itaconate derivatives, α-substituted enamides, α-arylenol acetates, and minimally functionalised olefins.

MATERIALS
Product Number
Brand
Product Description

Rhodium, foil, not light tested, 50x50mm, thickness 0.00025mm, permanent polyester support, 99.9%
Pricing and availability is not currently available.
Rhodium, wire reel, 0.05m, diameter 0.12mm, as drawn, 99.9%
Pricing and availability is not currently available.
Rhodium, foil, light tested, 25x25mm, thickness 0.075mm, as rolled, 99.9%
Pricing and availability is not currently available.
Rhodium, foil, not light tested, 25x25mm, thickness 0.001mm, permanent polyester support, 99.85%
Pricing and availability is not currently available.
Rhodium, wire reel, 0.05m, diameter 0.5mm, as drawn, 99.9%
Pricing and availability is not currently available.
Rhodium, foil, not light tested, 10x10mm, thickness 0.012mm, as rolled, 99.9%
Pricing and availability is not currently available.
Rhodium, foil, light tested, 25x25mm, thickness 0.05mm, as rolled, x-ray quality, 99.9%
Pricing and availability is not currently available.
Rhodium, wire reel, 0.2m, diameter 0.5mm, as drawn, 99.9%
Pricing and availability is not currently available.
Rhodium, foil, not light tested, 50x50mm, thickness 0.001mm, permanent polyester support, 99.85%
Pricing and availability is not currently available.
Rhodium, foil, 25x25mm, thickness 0.15mm, as rolled, 99.9%
Pricing and availability is not currently available.
Rhodium, wire reel, 0.05m, diameter 0.25mm, hard, 99.9%
Pricing and availability is not currently available.
Rhodium, foil, not light tested, 25x25mm, thickness 0.00025mm, permanent polyester support, 99.9%
Pricing and availability is not currently available.
Rhodium, foil, not light tested, 50x50mm, thickness 0.006mm, as rolled, 99.9%
Pricing and availability is not currently available.
Rhodium, foil, 25x25mm, thickness 0.1mm, as rolled, 99.9%
Pricing and availability is not currently available.
Rhodium, foil, light tested, 25x25mm, thickness 0.05mm, as rolled, 99.9%
Pricing and availability is not currently available.
Rhodium, microfoil, disks, 10mm, thinness 0.1μm, specific density 124μg/cm2, permanent mylar 3.5μm support, 99.9%
Pricing and availability is not currently available.
Rhodium, wire reel, 0.5m, diameter 0.12mm, as drawn, 99.9%
Pricing and availability is not currently available.
Rhodium, foil, not light tested, 25x25mm, thickness 0.00075mm, permanent polyester support, 99.85%
Pricing and availability is not currently available.
Rhodium, wire reel, 0.05m, diameter 1.0mm, as drawn, 99.9%
Pricing and availability is not currently available.
Rhodium, wire reel, 0.5m, diameter 0.25mm, hard, 99.9%
Pricing and availability is not currently available.
Rhodium, wire reel, 0.1m, diameter 0.12mm, as drawn, 99.9%
Pricing and availability is not currently available.
Rhodium, foil, 25x25mm, thickness 0.125mm, as rolled, 99.9%
Pricing and availability is not currently available.
Rhodium, foil, not light tested, 50x50mm, thickness 0.00075mm, permanent polyester support, 99.85%
Pricing and availability is not currently available.
Rhodium, foil, light tested, 15x15mm, thickness 0.05mm, as rolled, 99.9%
Pricing and availability is not currently available.
Rhodium, foil, not light tested, 25x25mm, thickness 0.006mm, as rolled, 99.9%
Pricing and availability is not currently available.
Rhodium, microfoil, disks, 25mm, thinness 0.1μm, specific density 124μg/cm2, permanent mylar 3.5μm support, 99.9%
Pricing and availability is not currently available.
Rhodium, foil, not light tested, 25x25mm, thickness 0.012mm, as rolled, 99.9%
Pricing and availability is not currently available.
Rhodium, microfoil, disks, 10mm, thinness 0.50μm, specific density 620μg/cm2, permanent mylar 3.5μm support, 99.99%
Pricing and availability is not currently available.
Sigma-Aldrich
Rhodium, powder, 99.95% trace metals basis
Pricing and availability is not currently available.
Rhodium, wire reel, 0.1m, diameter 0.5mm, as drawn, 99.9%
Pricing and availability is not currently available.