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  • Memory in humans is unaffected by central H1-antagonism, while objectively and subjectively measured sedation is increased.

Memory in humans is unaffected by central H1-antagonism, while objectively and subjectively measured sedation is increased.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (2010-01-20)
P Van Ruitenbeek, A Vermeeren, W J Riedel
ABSTRACT

Animal literature suggests an important role for histamine in memory. In humans, this hypothesis has been scarcely tested and results from studies that have addressed this are conflicting. Second, impaired memory performance may be secondary to sedation. This study aimed to determine whether a centrally active antihistamine impairs memory performance and to dissociate such effects from sedation. Eighteen healthy volunteers received single oral doses of dexchlorpheniramine 4 mg, lorazepam 1mg and placebo in a 3-way, double blind, crossover designed study. The active control lorazepam impaired episodic- and working memory performance and increased sedation, while dexchlorpheniramine only increased sedation.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
S-(+)-Chlorpheniramine maleate salt
Dexchlorpheniramine maleate, European Pharmacopoeia (EP) Reference Standard
Supelco
Chlorpheniramine Maleate, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
(±)-Chlorpheniramine maleate salt, ≥99% (perchloric acid titration)
Supelco
Chlorpheniramine maleate salt solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
Chlorphenamine maleate, European Pharmacopoeia (EP) Reference Standard