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PVP1

Sigma-Aldrich

Poly(vinylpyrrolidone)–Iodine complex

Synonym(s):

PVP-Iodine, Polyvinylpyrrolidone Iodine, PVP-I, Povadyne® antiseptic

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About This Item

CAS Number:
25655-41-8
MDL number:
MFCD00084483
UNSPSC Code:
51102829
PubChem Substance ID:
24899316
NACRES:
NA.85

form

powder

solubility

H2O: 100 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
fungi
parasites
viruses
yeast

Mode of action

protein synthesis | interferes

SMILES string

II.C=CN1CCCC1=O

InChI

1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)8;1-2/h2H,1,3-5H2;

InChI key

CPKVUHPKYQGHMW-UHFFFAOYSA-N

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Application

Poly(vinylpyrrolidone)–Iodine complex, or PVP-I, has been used to study microbial decontamination of human donor eyes and the inactivation of infectious hematopoietic necrosis virus.

Biochem/physiol Actions

PVP-1 is used as a slow iodine release formulation that iodinates lipids and oxidizes cell compounds such as tyrosine sidechains. It is used as a carbon nanotube coating agent to improve water solubility.

Other Notes

An iodophor; "tamed iodine."
Keep container tightly closed in a dry and well-ventilated place.

Legal Information

Povadyne is a registered trademark of National Patent Development Corp.

Pictograms

CorrosionEnvironment
GHS05,GHS09

Signal Word

Danger

Hazard Statements

H315,H318,H411

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

>212.0 °F - Not applicable

Flash Point(C)

> 100 °C - Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Yangzi Jiang et al.
Acta biomaterialia, 9(9), 8089-8098 (2013-05-28)
Polyvinylpyrrolidone-iodine (Povidone-iodine, PVP-I) is widely used as an antiseptic agent for lavation during joint surgery; however, the biological effects of PVP-I on cells from joint tissue are unknown. This study examined the biocompatibility and biological effects of PVP-I on cells
Lawrence L Yeung et al.
The Journal of urology, 189(1), 136-140 (2012-11-21)
We defined the relevant skin flora during genitourinary prosthetic surgery, evaluated the safety of chlorhexidine-alcohol for use on the male genitalia and compared chlorhexidine-alcohol to povidone-iodine in decreasing the rate of positive bacterial skin cultures at the surgical skin site
A Tuna et al.
Australian dental journal, 57(4), 435-439 (2012-11-29)
The aim of this pilot study was to evaluate the effects of mouthrinses containing 7.5% povidone iodine and 0.2% chlorhexidine on bacteraemia following impacted third molar surgery. Thirty-four patients were enrolled in this study. Patients in the first group were
Mitchell S Fineman et al.
Retina (Philadelphia, Pa.), 33(9), 1968-1970 (2013-04-24)
To describe an alternative technique for avoiding contact with the lids and eyelashes without the use of a metal lid speculum along with the results in clinical practice. Retrospective review of the medical records of all patients undergoing intravitreal injections
E Pels et al.
The British journal of ophthalmology, 83(9), 1019-1026 (1999-08-26)
Povidone-iodine (PVP -I) is applied for microbial decontamination of human eyes donated for transplantation. Concentrations and immersion times vary greatly. The effectiveness and toxicity of PVP-I were assessed for different decontamination protocols. Human donor eyes and corneas were immersed in
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