830865P

18:0 PA

Avanti Research^™ - A Croda Brand

• Synonym(s): 1,2-dioctadecanoyl-sn-glycero-3-phosphate (sodium salt); DSPA; PA(18:0/18:0)
• Empirical Formula (Hill Notation): C₃₉H₇₆O₈PNa
• CAS Number: 108321-18-2
• Molecular Weight: 726.98
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• description: 1,2-distearoyl-sn-glycero-3-phosphate (sodium salt)
• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 25 mg (830865P-25mg); pkg of 1 × 500 mg (830865P-500mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• lipid type: cardiolipins; phospholipids
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C39H77O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h37H,3-36H2,1-2H3,(H2,42,43,44);/q;+1/p-1/t37-;/m1./s1
• InChI key: ALPWRKFXEOAUDR-GKEJWYBXSA-M

Description

General description

Phosphatidic acid (PA) has two fatty acids and one phosphate group attached to a glycerol backbone. The two fatty acids are present at position sn-1 and sn-2 of the C-atoms and the phosphate group is present in the sn-3 position of the C-atom.

Application

18:0 PA may be used:

• as a component in the bilayer to study its vesiculation ability on different coat protein I (COPI) fission factor
• to study its effects on intracellular Ca²⁺ concentration ([Ca^2+]i) in C6 rat glioma and L2071 mouse fibroblast cells
• to study its effects on phosphorylation of cytochrome b(558) alpha chain (p22phox)

Biochem/physiol Actions

Phosphatidic acid (PA) acts as a biosynthetic precursor for the production of membrane glycerophospholipid and triacylglycerol. It participates in the modulation of mammalian target of rapamycin (mTOR) pathway. It may also participate in membrane trafficking, specifically in membrane fusion and fission.

Packaging

20 mL Clear Glass Screw Cap Vial (830865P-500mg)

5 mL Amber Glass Screw Cap Vial (830865P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable