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  • Acute retinal necrosis associated with Epstein-Barr virus: immunohistopathologic confirmation.

Acute retinal necrosis associated with Epstein-Barr virus: immunohistopathologic confirmation.

JAMA ophthalmology (2014-04-20)
Shlomit Schaal, Aleksandr Kagan, Yujuan Wang, Chi-Chao Chan, Henry J Kaplan
ABSTRACT

Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation. We report the clinical history and histopathologic confirmation that EBV can cause ARN. Clinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology. Epstein-Barr virus is a recognized cause of intraocular inflammation and has been implicated as a possible cause of ARN. However, to our knowledge, tissue demonstration of EBV in a patient with ARN has not previously been reported. We identified the organism in the necrotic retina of a patient receiving immunosuppression because of idiopathic pulmonary fibrosis.

MATERIALS
Product Number
Brand
Product Description

Supelco
Acyclovir, Pharmaceutical Secondary Standard; Certified Reference Material
Aciclovir, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Valacyclovir hydrochloride hydrate, ≥98% (HPLC), solid
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L-Valine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Supelco
L-Valine, Pharmaceutical Secondary Standard; Certified Reference Material
USP
Acyclovir, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
L-Valine, reagent grade, ≥98% (HPLC)
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Acycloguanosine, ≥99% (HPLC), powder
Sigma-Aldrich
L-Valine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
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L-Valine, BioUltra, ≥99.5% (NT)
SAFC
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Valaciclovir hydrochloride (anhydrous), European Pharmacopoeia (EP) Reference Standard
Valine, European Pharmacopoeia (EP) Reference Standard
USP
Valacyclovir hydrochloride, United States Pharmacopeia (USP) Reference Standard
Valaciclovir for system suitability, European Pharmacopoeia (EP) Reference Standard