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Key Documents

AV38825

Sigma-Aldrich

Anti-USP39 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-Ubiquitin specific peptidase 39

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

65 kDa

species reactivity

dog, human, rabbit, pig, rat

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_006581

UniProt accession no.

Q53GS9

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... USP39(10713)

Immunogen

Synthetic peptide directed towards the N terminal region of human USP39

Biochem/physiol Actions

USP39 is a ubiquitin specific peptidase, a neuronal slicing factor expressed in the brain. It maintains embryonic pituitary homeostasis in Zebrafish by regulating expansion of all embryonic pituitary cell lineages. USP39 controls the levels of aurora B mRNA and is important to maintain the integrity of mitotic spindle checkpoint.

Sequence

Synthetic peptide located within the following region: MSGRSKRESRGSTRGKRESESRGSSGRVKRERDREREPEAASSRGSPVRV

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chiharu Kimura-Yoshida et al.
Communications biology, 5(1), 378-378 (2022-04-21)
Previously, we have shown that the translocation of Grainyhead-like 3 (GRHL3) transcription factor from the nucleus to the cytoplasm triggers the switch from canonical Wnt signaling for epidermal differentiation to non-canonical Wnt signaling for epithelial morphogenesis. However, the molecular mechanism
Yesenia Ríos et al.
PLoS genetics, 7(1), e1001271-e1001271 (2011-01-21)
Loss of retinoblastoma (Rb) tumor suppressor function is associated with human malignancies. Molecular and genetic mechanisms responsible for tumorigenic Rb downregulation are not fully defined. Through a forward genetic screen and positional cloning, we identified and characterized a zebrafish ubiquitin
Renske J van Leuken et al.
Cell cycle (Georgetown, Tex.), 7(17), 2710-2719 (2008-08-30)
Accurate chromosome segregation relies on the mitotic spindle checkpoint. This checkpoint acts to restrict ubiquitin ligase activity of the Anaphase-promoting complex (APC/C) in mitosis until all chromosomes are bipolarly attached to the mitotic spindle. We performed a functional RNAi-based screen

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