I5532
Anti-Interleukin-21 Receptor, N-Terminal antibody produced in rabbit
~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-IL-21R
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
MDL number:
UNSPSC Code:
51111800
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~60 kDa
species reactivity
human
concentration
~0.5 mg/mL
technique(s)
western blot: 0.5-1 μg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... IL21R(50615)
Immunogen
synthetic peptide corresponding to amino acids 20-32 of human IL-21 receptor precursor.
Biochem/physiol Actions
Interleukin-21 (IL-21) is a cytokine that regulates both innate and adaptive immunity. The biological effects of IL-21 are mediated by a heterodimeric receptor made up of IL-21R and a γ chain subunit. IL-21R is expressed in liver, thymus, dendritic cells , lymph nodes and spleen. Binding of IL-21 to the receptor leads to activation of JAK (JAK1 and JAK3), STAT (STAT1, 3, 4 and 5) proteins. IL-21R is important for sustained T cell responses during chronic viral infections, production of interferons against pathogens and protection against tumor formation.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Not finding the right product?
Try our Product Selector Tool.
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Giovanni Monteleone et al.
Discovery medicine, 8(42), 113-117 (2009-10-17)
Interleukin-21 (IL-21), a cytokine produced by activated CD4+ T cells, activated natural killer T cells, and T follicular cells, has been reported to play a crucial role in the tissue-damaging T cell response in various organs, such as gut, skin
Massimiliano Sarra et al.
Journal of biomedicine & biotechnology, 2010, 294582-294582 (2010-07-24)
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterized by excessive production of a variety of autoantibodies and a wide range of clinical manifestations. Pathogenesis of SLE is complex and not fully understood. There is however evidence that B and
John S Yi et al.
Microbes and infection, 12(14-15), 1111-1119 (2010-09-08)
Interleukin-21 (IL-21) is a cytokine that has broad effects on both innate and adaptive immune responses. The roles of IL-21 in determining immunity to infections are currently being defined, and notably, it has been shown that IL-21 is most critical
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
