34857

1,4-Dioxane

suitable for HPLC, ≥99.5%

• Synonym(s): Diethylene oxide, Dioxane
• Empirical Formula (Hill Notation): C₄H₈O₂
• CAS Number: 123-91-1
• Molecular Weight: 88.11
• Beilstein: 102551
• EC Number: 204-661-8
• MDL number: MFCD00006571
• UNSPSC Code: 41116105
• PubChem Substance ID: 329755066
• NACRES: NA.21

Properties

• vapor density: 3 (vs air)
• vapor pressure: 27 mmHg ( 20 °C); 40 mmHg ( 25 °C)
• Assay: ≥99.5%
• form: liquid
• autoignition temp.: 356 °F
• expl. lim.: 22 %
• technique(s): HPLC: suitable
• impurities: ≤0.001% non-volatile matter; ≤0.002% free acid (as CH₃COOH); ≤0.01% peroxides (as H₂O₂); ≤0.05% water (Karl Fischer)
• transmittance: 220 nm, ≥20%; 270 nm, ≥80%; 300 nm, ≥98%
• refractive index: n20/D 1.422 (lit.)
• pH: 6.0-8 (20 °C, 500 g/L)
• bp: 100-102 °C (lit.)
• mp: 10-12 °C (lit.)
• density: 1.034 g/mL at 25 °C (lit.)
• UV absorption: λ: 220 nm A_max: ≤0.70; λ: 235 nm A_max: ≤0.50; λ: 250 nm A_max: ≤0.20; λ: 270 nm A_max: ≤0.10; λ: 295-400 nm A_max: ≤0.01
• application(s): food and beverages
• SMILES string: C1COCCO1
• InChI: 1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2
• InChI key: RYHBNJHYFVUHQT-UHFFFAOYSA-N

Description

General description

1,4-Dioxane is widely used as a solvent for various organic compounds in industry. It is a non-biodegradable contaminant found in industrial effluents. Its oxidative degradation by using oxygen and ozone has been useful in converting it into biodegradable products, which can be easily removed by conventional methods.

Application

1,4-Dioxane may be employed as a solvent in the synthesis of N-(4-(prop-2-ynyloxy)phenyl)acetamide and 3-(4-(prop-2-ynyloxy)phenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine.

High-purity, multipurpose solvent, tested for suitability in:

• HPLC
• Spectrophotometry
• Residual testing
• LC-MS applications.

Reported as a solvent in:

• HPLC-MS study of fat-soluble vitamins (FSVs)
• GC-MS analysis of phthalates in workplace air

Suitable for HPLC, spectrophotometry, environmental testing

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Safety Information

• Pictograms: GHS02,GHS08,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H319,H335,H350
• Precautionary Statements: P202 - P210 - P233 - P240 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• Target Organs: Respiratory system
• Supplementary Hazards: EUH019,EUH066
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 51.8 °F - closed cup
• Flash Point(C): 11 °C - closed cup