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  • Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity.

Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity.

Immunologic research (2013-04-24)
C A Shaw, L Tomljenovic
ABSTRACT

We have examined the neurotoxicity of aluminum in humans and animals under various conditions, following different routes of administration, and provide an overview of the various associated disease states. The literature demonstrates clearly negative impacts of aluminum on the nervous system across the age span. In adults, aluminum exposure can lead to apparently age-related neurological deficits resembling Alzheimer's and has been linked to this disease and to the Guamanian variant, ALS-PDC. Similar outcomes have been found in animal models. In addition, injection of aluminum adjuvants in an attempt to model Gulf War syndrome and associated neurological deficits leads to an ALS phenotype in young male mice. In young children, a highly significant correlation exists between the number of pediatric aluminum-adjuvanted vaccines administered and the rate of autism spectrum disorders. Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Aluminum, foil, thickness 8 μm, 99% trace metals basis
Aluminum, IRMM®, certified reference material, 1.0 mm foil
Sigma-Aldrich
Aluminum, pellets, 3-8 mesh, ≥99.999% trace metals basis
Sigma-Aldrich
Aluminum, granular, <1 mm, 99.7% trace metals basis
Sigma-Aldrich
Aluminum, wire, diam. 0.58 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Aluminum, wire, diam. 1.0 mm, 99.999% trace metals basis
Sigma-Aldrich
Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis
Aluminum, IRMM®, certified reference material, 1.0 mm wire
Aluminum, insulated wire, 20m, conductor diameter 0.1mm, insulation thickness 0.005mm, polyimide insulation, 99.95+%
Aluminum, mesh, 900x900mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh
Aluminum, microfoil, disks, 25mm, thinness 1.0μm, specific density 269.9μg/cm2, permanent mylar 3.5μm support, 99.999%
Aluminum, insulated wire, 2m, conductor diameter 0.1mm, insulation thickness 0.005mm, polyimide insulation, 99.95+%
Aluminum, microleaf disks, 25mm, thinness 0.15μm, specific density 41.28μg/cm2, removable support, 99.999%
Aluminum, microleaf disks, 25mm, thinness 0.25μm, specific density 68.8μg/cm2, removable support, 99.999%
Aluminum, sphere, 100pcs, diameter 6.0mm, 99%
Aluminum, tube, 500mm, outside diameter 3.0mm, inside diameter 1.62mm, wall thickness 0.69mm, hard, 99.5%
Aluminum, microleaf disks, 25mm, thinness 0.5μm, specific density 120.6μg/cm2, removable support, 99.999%
Aluminum, rod, 100mm, diameter 28mm, as drawn, 99.999%
Aluminum, wire reel, 500m, diameter 1.0mm, as drawn, 99.95+%
Aluminum, wire reel, 20m, diameter 0.02mm, hard, 99.99%
Aluminum, wire reel, 10m, diameter 1.5mm, as drawn, 99.999%
Aluminum, wire reel, 500m, diameter 0.30mm, as drawn, 99.5%
Aluminum, wire reel, 10m, diameter 0.015mm, hard, 99.99%
Aluminum, wire reel, 2m, diameter 0.25mm, as drawn, 99.999%
Aluminum, wire reel, 200m, diameter 0.25mm, as drawn, 99.95+%
Aluminum, wire reel, 20m, diameter 0.25mm, hard, 99.99+%
Aluminum, wire reel, 10m, diameter 0.025mm, as drawn, 99.0+%
Aluminum, wire reel, 20m, diameter 1.0mm, as drawn, 99.5%
Aluminum, wire reel, 5m, diameter 0.30mm, as drawn, 99.5%
Aluminum, wire reel, 50m, diameter 0.5mm, as drawn, 99.95+%