Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Journal of inorganic biochemistry (2011-11-22)

Maire E Percy, Theo P A Kruck, Aileen I Pogue, Walter J Lukiw

PMID22099160

ABSTRACT

In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was reported to slow the progression of Alzheimer's disease (AD) by a factor of two. Twenty years later this promising trial has not been followed up and why this treatment worked still is not clear. In this critical interdisciplinary review, we provide an overview of the complexities of AD and involvement of metal ions, and revisit the neglected DFO trial. We discuss research done by us and others that is helping to explain involvement of metal ion catalyzed production of reactive oxygen species in the pathogenesis of AD, and emerging strategies for inhibition of metal-ion toxicity. Highlighted are insights to be considered in the quests to prevent potentially toxic effects of aluminum toxicity and prevention and intervention in AD.

MATERIALS

Product Number

Brand

Product Description

266523

Sigma-Aldrich

Aluminum, ReagentPlus^®, beads, 5-15 mm, 99.9% trace metals basis

GF85240694

Aluminum, honeycomb, 600x600mm, thickness 20mm, cell size 3.2mm, cell wall 0.025mm, core density 0.072g/cm³, phenolic adhesive (resin), 99.5%

GF31987525

Aluminum, honeycomb, 300x300mm, thickness 10mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm³, phenolic adhesive (resin), 99.5%

GF24569602

Aluminum, foam, 150x150mm, thickness 30mm, bulk density 0.2g/cm³, porosity 0.93, aluminum 6101 grade, 98.5%

GF26773230

Aluminum, honeycomb, 300x300mm, thickness 13.9mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm³, phenolic adhesive (resin), facing skin aluminum 0.55mm, 99.9%

GF03467202

Aluminum, honeycomb, 300x300mm, thickness 52.3mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm³, phenolic adhesive (resin), facing skin glass fiber 0.75mm, 99.9%

GF86118969

Aluminum, honeycomb, 300x300mm, thickness 5mm, cell size 19mm, cell wall 0.064mm, core density 0.029g/cm³, phenolic adhesive (resin), 99.5%

GF33400224

Aluminum, honeycomb, 600x600mm, thickness 52.3mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm³, phenolic adhesive (resin), facing skin glass fiber 0.75mm, 99.9%

GF63970498

Aluminum, honeycomb, 300x300mm, thickness 26.5mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm³, phenolic adhesive (resin), facing skin carbon fiber / epoxy, 99.9%

GF87997000

Aluminum, honeycomb, 300x300mm, thickness 20mm, cell size 4.8mm, cell wall 0.038mm, core density 0.070g/cm³, phenolic adhesive (resin), 99.5%

GF98440027

Aluminum, honeycomb, 600x600mm, thickness 10mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm³, phenolic adhesive (resin), 99.5%

GF19760081

Aluminum, honeycomb, 600x600mm, thickness 5mm, cell size 3.2mm, cell wall 0.025mm, core density 0.072g/cm³, phenolic adhesive (resin), 99.5%

GF58771301

Aluminum, honeycomb, 600x600mm, thickness 5mm, cell size 13mm, cell wall 0.1mm, core density 0.062g/cm³, phenolic adhesive (resin), 99.5%

GF23840221

Aluminum, honeycomb, 300x300mm, thickness 26.5mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm³, phenolic adhesive (resin), facing skin aluminum 0.55mm, 99.9%

GF95990068

Aluminum, wire reel, 100m, diameter 0.25mm, hard, 99.99+%

GF21896039

Aluminum, rod, 200mm, diameter 12.0mm, as drawn, 99.999%

GF40404574

Aluminum, wire reel, 100m, diameter 0.25mm, as drawn, 99.5%

GF31334093

Aluminum, wire reel, 0.5m, diameter 0.5mm, as drawn, 99.999%

GF95825403

Aluminum, sphere, 100pcs, diameter 3.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

GF08137166

Aluminum, wire reel, 1000m, diameter 0.7mm, as drawn, 99.5%

GF06074120

Aluminum, wire reel, 0.5m, diameter 1.0mm, as drawn, 99.999%

GF68037723

Aluminum, wire reel, 1000m, diameter 0.30mm, as drawn, 99.5%

GF09755837

Aluminum, wire reel, 100m, diameter 0.5mm, as drawn, 99.95+%

GF71298546

Aluminum, wire reel, 100m, diameter 0.063mm, annealed, 99.99%

GF52495500

Aluminum, tube, 0.1m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%

GF94706354

Aluminum, mesh, 150x150mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF70373505

Aluminum, microleaf disks, 10mm, thinness 1.0μm, specific density 269.9μg/cm², removable support, 99.999%

GF19654803

Aluminum, rod, 200mm, diameter 5.0mm, as drawn, 99.999%

GF72634103

Aluminum, rod, 50mm, diameter 28mm, as drawn, 99.999%

GF62984346

Aluminum, tube, 2m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%