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SML1101

Sigma-Aldrich

Nedocromil sodium

≥98% (HPLC)

Synonym(s):

9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid sodium salt, Nedocromil disodium salt

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10 MG
€77.90
50 MG
€298.00

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10 MG
€77.90
50 MG
€298.00

About This Item

Empirical Formula (Hill Notation):
C19H15NO7 · 2 Na
CAS Number:
69049-74-7
Molecular Weight:
415.30
UNSPSC Code:
12352200
NACRES:
NA.77

€77.90

Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

, white to beige to brown

solubility

H2O: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

[Na+].[Na+].[n]1(c2c([c](cc1C(=O)[O-])=O)cc3c([o]c(c[c]3=O)C(=O)[O-])c2CCC)CC

InChI

1S/C19H17NO7.2Na/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11;;/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26);;/q;2*+1/p-2

InChI key

JQEKDNLKIVGXAU-UHFFFAOYSA-L

Biochem/physiol Actions

Nedocromil is a mast cell stabilizer and anti-inflammatory and anti-allergic drug.
Nedocromil is a mast cell stabilizer and anti-inflammatory and anti-allergic drug. Nedocromil inhibits the degranulation of mast cells, and prevents the activation of and mediator release from a variety of inflammatory cell types. Nedocromil inhibits release of histamine, leukotriene C4, and prostaglandin D2, but has no antihistamine, bronchodilator, or corticosteroid activity itself.
Nedocromil is considered to be more effective in treating asthma compared to a placebo.[1]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000413837
0000413837
0000186657
0000186656
0000186656

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Is nedocromil sodium effective treatment for asthma?
O'Byrne P M and Cook D
The European Respiratory Journal, 6(1), 5-6 (1993)
Ajantha Sinniah et al.
International immunopharmacology, 32, 87-95 (2016-01-25)
1.We investigated the role of Annexin (ANX)-A1 and its receptor, ALX/FPR2, in the regulation of mast cell degranulation produced by compound 48/80. 2.Both human cord-blood derived mast cells (CBDMCs) and murine bone marrow derived mast cells (BMDMCs) release phosphorylated ANX-A1

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