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915408

Sigma-Aldrich

NanoFabTx™ PEGylated nanoparticle formulation screening kit

Synonym(s):

NanoFabTx™ reagent kit, Nanoparticle synthesis kit, PEGylated nanoformulations

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.23

description

Kit components :
PEGPLGA-50L (912808-500mg)
PEGPLGA-75L (913049-500mg)
PEGPLA-L (913308-500mg)
PEGPCL-H (912549-500mg)
Stabilizer - P (913448-10g)
Materials screening kit, for synthesis of PEGylated polymeric nanoparticles

Quality Level

100

application(s)

advanced drug delivery

storage temp.

2-8°C

General description

NanoFabTx™ PEGylated nanoparticle formulation screening kit contains optimized reagents and protocols for nanoprecipiation and microfluidic-based synthesis of polymer nanoparticles. The kit provides rationally selected PEGylated PLGA, PLA, and PCL polymers, which are widely used in drug delivery systems for controlled drug release of many different types of therapeutic molecules. This reagent kit can be combined with the NanoFabTx™ Microfluidic - nano device kit (Cat.No. 911593) for microfluidic synthesis of polymer nanoparticles 60 to 100 nm in size.

Application

NanoFabTx™ PEGylated nanoparticle formulation screening kit is designed for the synthesis of specifically sized, hydrophobic drug encapsulated biodegradable PEGylated polymer nanoparticles. Our specially designed PEGylated polymers result in nanoparticles with a PEG surface coating that reduces protein absorption and prolongs circulation time, leading to slow and sustained release of the encapsulated drug. The NanoFabTx™ PEGylated nanoparticle formulation screening kit enables nanoparticle optimization by selection of the right polymer to achieve the desired nanoparticle size, drug encapsulation, release kinetics, and stability in systemic circulation. This kit provides reagents and protocols for nanoprecipitation and microfluidics to synthesize 60 nm to 100 nm nanoparticles.

Features and Benefits

  • Provides step-by-step protocols, both for standard extrusion or microfluidic-based synthesis, developed and tested by our formulation scientists
  • Microfluidic formulation development for enhancing drug bioavailability
  • Flexible synthesis tool to create uniform and reproducible nanoparticles
  • Optimized to make nanoparticles from 60-100 nm
  • Includes 4 different PEGylated polymers to identify the optimal material

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

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Storage Class Code

12 - Non Combustible Liquids

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S Freiberg et al.
International journal of pharmaceutics, 282(1-2), 1-18 (2004-09-01)
Polymer microspheres can be employed to deliver medication in a rate-controlled and sometimes targeted manner. Medication is released from a microsphere by drug leaching from the polymer or by degradation of the polymer matrix. Since the rate of drug release
C Thomasin et al.
Journal of pharmaceutical sciences, 87(3), 269-275 (1998-04-02)
Phase separation (frequently called coacervation) of poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA) is a classical method for drug microencapsulation. Here, attempts have been made to describe this process in the light of thermodynamics. Different PLA/PLGAs were dissolved in either dichloromethane or
Nazila Kamaly et al.
Chemical Society reviews, 41(7), 2971-3010 (2012-03-06)
Polymeric materials have been used in a range of pharmaceutical and biotechnology products for more than 40 years. These materials have evolved from their earlier use as biodegradable products such as resorbable sutures, orthopaedic implants, macroscale and microscale drug delivery
Verónica Lassalle et al.
Macromolecular bioscience, 7(6), 767-783 (2007-06-02)
The controlled release of medicaments remains the most convenient way of drug delivery. Therefore, a wide variety of reports can be found in the open literature dealing with drug delivery systems. In particular, the use of nano- and microparticles devices
Byung Kook Lee et al.
Advanced drug delivery reviews, 107, 176-191 (2016-06-06)
Poly(d,l-lactic acid) (PLA) has been widely used for various biomedical applications for its biodegradable, biocompatible, and nontoxic properties. Various methods, such as emulsion, salting out, and precipitation, have been used to make better PLA micro- and nano-particle formulations. They are
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