- Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance.
Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance.
Scientific reports (2017-07-01)
Théo Araújo-Santos, Bruno B Andrade, Leonardo Gil-Santana, Nívea F Luz, Priscila L Dos Santos, Fabrícia A de Oliveira, Meirielly Lima Almeida, Roseane Nunes de Santana Campos, Patrícia T Bozza, Roque P Almeida, Valeria M Borges
PMID28659627
ABSTRACT
Visceral leishmaniasis (VL) remains a major public health problem worldwide. Cytokine balance is thought to play a critical role in the development of this disease. Here, we perform a prospective exploratory study addressing whether simultaneous assessment of circulating levels of different lipid mediators and cytokines could highlight specific pathways involved with VL pathogenesis. VL patients displayed substantial increases in serum levels of Prostaglandin F
MATERIALS