- Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry.
Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry.
Chemical communications (Cambridge, England) (2015-01-13)
F Cagide, T Silva, J Reis, A Gaspar, F Borges, L R Gomes, J N Low
PMID25579652
ABSTRACT
The discovery of potent and selective monoamine oxidase-B inhibitors for the management of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is still a challenging endeavor. Herein, we report the discovery of two new classes of potent and selective MAO-B inhibitors based on chromane-2,4-dione and chromone-3-carboxamide scaffolds.
MATERIALS