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1269221

USP

Famotidine Related Compound B

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

N,N′′′-[(1,1-Dioxido-2H-1,2,4,6-thiatriazine-3,5-diyl)bis(2,1-ethanediylthiomethylene-4,2-thiazolediyl)]bisguanidine, 3,5-Bis[2-[[[2-[(diaminomethylene)amino]thiazol-4-yl]methyl]sulphanyl]ethyl]-4H-1,2,4,6-thiatriazine 1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):
C16H23N11O2S5
CAS Number:
Molecular Weight:
561.75
UNSPSC Code:
41116107
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

agency

USP

API family

famotidine

form

powder

packaging

pkg of 25 mg

manufacturer/tradename

USP

storage condition

protect from light

color

yellow to white

solubility

water: soluble

application(s)

pharmaceutical (small molecule)

format

neat

InChI

1S/C16H23N11O2S5/c17-13(18)24-15-21-9(7-32-15)5-30-3-1-11-23-12(27-34(28,29)26-11)2-4-31-6-10-8-33-16(22-10)25-14(19)20/h7-8H,1-6H2,(H,23,26,27)(H4,17,18,21,24)(H4,19,20,22,25)

InChI key

NRRXZFHNRLQONH-UHFFFAOYSA-N

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General description

Famotidine Related Compound B (Famotidine Impurity B) is an impurity of famotidine, which is a hydrophilic, cationic, histamine H2 receptor antagonist drug that effectively inhibits gastric acid secretion in humans.

Application

Famotidine Related Compound B USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monograph such as Famotidine

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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High-performance thin-layer chromatography for the determination of ranitidine hydrochloride and famotidine in pharmaceuticals.
Novakovic J.
Journal of Chromatography A, 846(1-2), 193-198 (1999)
Capillary zone electrophoresis method for the determination of famotidine and related impurities in pharmaceuticals
Helali N, et al.
Talanta, 74(4) (2008)
Famotidine
Pharmacopeia, US
United States Pharmacopeia, 39(1)(1-2), 1815-1815 (2020)
Potentiometric determination of famotidine in pharmaceutical formulations
Ayad MM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 29(1-2) (2002)
Photoaffinity labeling of the anionic sites in Caco-2 cells mediating saturable transport of hydrophilic cations ranitidine and famotidine
Bourdet DL, et al.
Journal of medicinal chemistry, 47(11) (2004)

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