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T2255

Trifluorothymidine

≥99% (HPLC), synthetic, powder

Synonym(s):

α,α,α-Trifluorothymidine, 2′-Deoxy-5-trifluoromethyluridine, Trifluorothymine deoxyriboside, Trifluridine

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100 mg
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$318.00
1 g
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$2,080.00

About This Item

Empirical Formula (Hill Notation):
C10H11F3N2O5
CAS Number:
70-00-8
Molecular Weight:
296.20
NACRES:
NA.51
PubChem Substance ID:
24900027
UNSPSC Code:
41106305
EC Number:
200-722-8
MDL number:
MFCD00006534
Assay:
≥99% (HPLC)
Biological source:
synthetic
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C

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Product Name

Trifluorothymidine, ≥99% (HPLC)

biological source

synthetic

Quality Segment

100

assay

≥99% (HPLC)

form

powder

mp

190-193 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(C(=O)NC2=O)C(F)(F)F

InChI

1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1

InChI key

VSQQQLOSPVPRAZ-RRKCRQDMSA-N

Application

Trifluorothymidine has been used as a component of selection medium to screen thymidine kinase (TK) mutants in lymphoma cells, human lymphoblastoid TK6 cells, and L5178Y mouse lymphoma cells.

Biochem/physiol Actions

Trifluorothymidine is a thymidine analog and is light sensitive. TFT serves as a thymidine kinase substrate to study enzyme specificity and kinetics. Incorporation of phosphorylated TFT into DNA induces damage, making it useful for DNA repair studies. TFT may also be used in the inhibition of thymidylate synthase and in screening mutant thymidine kinase gene.. It elicits antitumor activity in gastrointestinal (GI) cancers and has therapeutic potential to treat herpetic keratitis.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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This Item
1686309PHR3150BP1126
Trifluorothymidine ≥99% (HPLC)

Sigma-Aldrich

T2255

Trifluorothymidine

Trifluridine United States Pharmacopeia (USP) Reference Standard

USP

1686309

Trifluridine

Trifluridine pharmaceutical secondary standard, certified reference material

Supelco

PHR3150

Trifluridine

Trifluridine British Pharmacopoeia (BP) Reference Standard

BP1126

Trifluridine

description

≥99% (HPLC)

description

United States Pharmacopeia (USP) Reference Standard

description

pharmaceutical secondary standard, certified reference material

description

British Pharmacopoeia (BP) Reference Standard

biological source

synthetic

biological source

-

biological source

-

biological source

-

Quality Level

100

Quality Level

-

Quality Level

300

Quality Level

-

form

powder

form

-

form

-

form

solid

assay

≥99% (HPLC)

assay

-

assay

-

assay

-

solubility

water: 50 mg/mL, clear, colorless

solubility

-

solubility

-

solubility

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

pictograms

Health hazard
GHS08

signalword

Warning

Hazard Classifications

Carc. 2 - Muta. 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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