SML3543
SGC-UBD253N
≥98% (HPLC)
Synonym(s):
3-(8-Chloro-3-(2-((2-methoxybenzyl)(methyl)amino)-2-oxoethyl)-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid
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About This Item
Empirical Formula (Hill Notation):
C22H22ClN3O5
Molecular Weight:
443.88
UNSPSC Code:
12352200
NACRES:
NA.21
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
SGC-UBD253N is a closely related negative control (KD = 32 µM) for SGC-UBD253 a chemical probe for the ubiquitin binding domain (UBD) of HDAC6.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Renato Ferreira de Freitas et al.
Journal of medicinal chemistry, 61(10), 4517-4527 (2018-05-10)
HDAC6 plays a central role in the recruitment of protein aggregates for lysosomal degradation and is a promising target for combination therapy with proteasome inhibitors in multiple myeloma. Pharmacologically displacing ubiquitin from the zinc-finger ubiquitin-binding domain (ZnF-UBD) of HDAC6 is
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