DAPTA is a potent CCR5 antagonist, an amidated octapeptide corresponding to an HIV envelope glycoprotein gp120 (gp160)-derived sequence (aa 185-192; the SF-2 isolate) that competes against gp120-CD4 complex for interaction with CCR5 (IC50 = 0.42 nM against gp120CM235 binding to CCR5/CD4 cells, IC50 = 1.5/1.8 nM against gp120BaL/sCD4 or gp120CM235/sCD4 binding to CCR5+/CD4- cells). DAPTA blocks CCR5-dependent HIV host cell entry in cultures and in vivo.
Potent CCR5 antagonist that blocks CCR5-dependent HIV host cell entry in cultures and in vivo.
Chronic neuroinflammation plays a prominent role in the progression of Alzheimer's disease. Reactive microglia and astrocytes are observed within the hippocampus during the early stages of the disease. Epidemiological findings suggest that anti-inflammatory therapies may slow the onset of Alzheimer's
The chemokine receptor CCR5 plays a crucial role in transmission of HIV isolates, which predominate in the early and middle stages of infection, as well as those, which populate the brain and cause neuro-AIDS. CCR5 is therefore an attractive therapeutic
AIDS (London, England), 34(7), 979-988 (2020-02-20)
Postmortem brains of patients diagnosed with HIV-1-associated neurocognitive disorders (HAND) exhibit loss of dendrites. However, the mechanisms by which synapses are damaged are not fully understood. Dendrite length and remodeling occurs via microtubules, the dynamics of which are regulated by
Frontiers in pharmacology, 12, 551839-551839 (2021-05-07)
Background: Cigarette smoke exposure (CSE) is a major cause of chronic obstructive pulmonary disease (COPD). The smoke disrupts cell-cell adhesion by inducing epithelial barrier damage to the tight junction (TJ) proteins. Even though the inflammatory mechanism of chemokine (C-C motif)
The Journal of investigative dermatology, 110(4), 332-337 (1998-04-16)
In addition to acquired immunodeficiency syndrome (AIDS), persons infected with human immunodeficiency virus often develop cutaneous manifestations, including severe psoriasis. In previous studies, we have established that psoriatic fibroblasts and erythrocytes obtained from psoriatic patients exhibit decreased levels of cyclic
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