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SML2993

JH-RE-06

≥98% (HPLC)

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Synonym(s):

8-Chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-4(1H)-quinolinone

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$137.00
25 mg

Available to ship TODAYfromMILWAUKEE

$525.00

About This Item

Empirical Formula (Hill Notation):
C20H16Cl3N3O4
CAS Number:
Molecular Weight:
468.72
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$137.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Clc1c(ccc(c1)Cl)Nc2[nH]c3c([c](c2C(=O)CC(C)C)=O)c(ccc3Cl)[N+](=O)[O-]

InChI

1S/C20H16Cl3N3O4/c1-9(2)7-15(27)17-19(28)16-14(26(29)30)6-4-11(22)18(16)25-20(17)24-13-5-3-10(21)8-12(13)23/h3-6,8-9H,7H2,1-2H3,(H2,24,25,28)

InChI key

LRTXIQCBQIKIOH-UHFFFAOYSA-N

Biochem/physiol Actions

JH-RE-06 is a potent and selective inhibitor of REV1-REV7 interaction that induces REV1 dimerization blocking the REV1-REV7 interaction and POL ϲ recruitment. JH-RE-06 potently inhibits translesion synthesis (TLS) and augments cisplatin effectiveness in cultured human and mouse cell lines. It improves effectiveness of cisplatin in A375 tumor xenograft mouse model.
potent and selective inhibitor of REV1-REV7 interaction blocking the REV1-REV7 interaction and POL ϲ recruitment

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This Item
SML3644SML1274SML1094
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (Warmed)

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 0.5 mg/mL, clear (warmed)

color

white to beige

color

white to beige

color

yellow to orange

color

white to brown


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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