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SML2832

5-Amino-1-methylquinolinium iodide

≥98% (HPLC)

Synonym(s):

5-Amino-1-MQ iodide, 5-Amino-1-methylquinolinium, iodide (1:1), 5-Amino-1MQ iodide

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Size/SKUAvailabilityPrice
5 mg
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$108.00
25 mg
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$420.00

About This Item

Empirical Formula (Hill Notation):
C10H11N2·I
CAS Number:
42464-96-0
Molecular Weight:
286.11
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$108.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

faint red to dark brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

C[N+]1=CC=CC2=C(C=CC=C12)N.[I-]

InChI

1S/C10H10N2.HI/c1-12-7-3-4-8-9(11)5-2-6-10(8)12;/h2-7,11H,1H3;1H

InChI key

JPEZFBFIRRAFNR-UHFFFAOYSA-N

Biochem/physiol Actions

5-Amino-1-methylquinolinium (5-amino-1MQ) is a substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM; 50 μM SAM, 100 μM NCA) that reduces 3T3-L1 lipogenesis (EC50 = 30μM) and adipocytes 1-methylnicotinamide level (EC50 = 2.3 μM) without affecting related methyltransferases & enzymes in the NAD+ salvage pathway. 5-amino-1MQ shows in vivo therapeutic efficacy in murine models of DIO (20 mg/kg/d sc.), muscle injury (5 or 10 mg/kg bid. sc.), and intraperitoneal HeyA8 ovarian cancer metastasis (20 mg/kg/d ip.) with no adverse effects to the animals (up to 60 mg/kg/d). Note:1.89 mg iodide salt contains 1 mg eq of 5-amino-1MQ.
Substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor with in vitro and in vivo efficay.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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Questions

1–2 of 2 Questions  

  1. Can there be a chloride salt version that is white?

    1 answer

    1. Unfortunately, the iodide form of this compound is the only product option available at this time.

      Helpful?

  2. Does 5 amino 1MQ have iodine in it? 

    1 answer

    1. Yes, iodine is present as this product is the iodide salt of 5-Amino-1MQ . This is not a covalent bond and the Iodine will ionize in solution. Please see the link below to review a sample Certificate of Analysis:
      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/SML2832-5MG0000102634.pdf

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