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SML2812

AN1

≥98% (HPLC)

Synonym(s):

5-Bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one, mHTT-LC3 linker AN1

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$104.00
$88.40
25 mg

Available to ship TODAYfromMILWAUKEE

$420.00
$357.00

About This Item

Empirical Formula (Hill Notation):
C15H9Br2NO3
CAS Number:
Molecular Weight:
411.04
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$88.40

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Brc1c(c(cc(c1)C=C2c3c(ccc(c3)Br)NC2=O)O)O

InChI

1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)

InChI key

GPKLWRHHVIBYEO-UHFFFAOYSA-N

Biochem/physiol Actions

AN1 is a brain blood barrier penetrant agent that tether LC3 and mHTT and targets mHTT for autophagosome degradation. AN1 significantly lower mHTT in cortices of HD mice, in cells from patients with Huntington′s disease, and neurons derived from induced pluripotent stem cells. AN1 does not lower wtHTT in fibroblasts from healthy human donors. It appears that AN1 interact with the polyQ stretch.
brain blood barrier penetrant agent that tether LC3 and mHTT and targets mHTT for autophagosome degradation

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This Item
L2545SML0531SML2753
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: >20 mg/mL

solubility

H2O: 2 mg/mL (clear solution, warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

off-white

color

, dark red to purple

color

white to beige


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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