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SML2801

Isoforskolin

≥95% (HPLC)

Synonym(s):

6-Acetyl-7-deacetylforskolin, (3R,6S,6aS)-6-(acetyloxy)-3-ethenyldodecahydro-5S,10S,10bS-trihydroxy-3,4aR,7,7,10aR-pentamethyl-1H-naphtho[2,1-b]pyran-1-one, Coleonol B, 6β-Acetoxy-1α,7β,9α-trihydroxy-8,13-epoxy-labd-14-en-11-one, Isoforskolin

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5 mg
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$88.20
25 mg
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$295.00

About This Item

Empirical Formula (Hill Notation):
C22H34O7
CAS Number:
64657-21-2
Molecular Weight:
410.50
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00078929
Assay:
≥95% (HPLC)
Form:
powder

$88.20

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Quality Segment

100

assay

≥95% (HPLC)

form

powder

optical activity

[α]/D -8 to -5°, c = 0.5 in chloroform-d

color

white to beige

solubility

DMF:H2O (9:1): 2 mg/mL, clear

storage temp.

−20°C

SMILES string

CC(=O)O[C@@H]1[C@H](O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)C13)C=C

InChI

1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1

InChI key

CLOQVZCSBYBUPB-VDCUXWMXSA-N

Biochem/physiol Actions

Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a rat asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling.

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This Item
PHL82566F3917D3658
Isoforskolin ≥95% (HPLC)

Sigma-Aldrich

SML2801

Isoforskolin

Isoforskolin phyproof® Reference Substance

PHL82566

Isoforskolin

Forskolin For use in molecular biology applications

Sigma-Aldrich

F3917

Forskolin

1,9-Dideoxyforskolin from Coleus forskohlii ≥97%, solid

Sigma-Aldrich

D3658

1,9-Dideoxyforskolin from Coleus forskohlii

description

≥95% (HPLC)

description

phyproof® Reference Substance

description

For use in molecular biology applications

description

≥97%, solid

assay

≥95% (HPLC)

assay

≥90.0% (HPLC)

assay

≥98% (HPLC)

assay

≥97%

form

powder

form

solid

form

powder

form

solid

Quality Level

100

Quality Level

-

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

-

storage temp.

room temp

storage temp.

−20°C

solubility

DMF:H2O (9:1): 2 mg/mL, clear

solubility

-

solubility

ethanol: soluble

solubility

methanol: 28 mg/mL(lit.), DMSO: 3 mg/mL(lit.), chloroform: 50 mg/mL, ethanol: 6.6 mg/mL(lit.), dilute aqueous acid and base: insoluble(lit.)

color

white to beige

color

-

color

white to off-white

color

white to off-white

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signalword

Warning

pictograms

Exclamation mark
GHS07

hcodes

H312

Hazard Classifications

Acute Tox. 4 Dermal

Storage Class

11 - Combustible Solids

wgk

WGK 3

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